109451
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
PtPdNi 三金属掺杂 MIL-88 水凝胶加速糖尿病细菌感染伤口愈合
Authors Peng Y, Du W, Cui Y, Su C, Liu Y, Bai Y, Li W, Zhang J, Wang X, Fu S, Zhu H
Received 13 May 2025
Accepted for publication 29 September 2025
Published 29 October 2025 Volume 2025:20 Pages 13113—13132
DOI https://doi.org/10.2147/IJN.S540126
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Xing Zhang
Yawen Peng,1,2,* Wenjuan Du,3,* Yating Cui,1,* Chenri Su,4 Yuyu Liu,1 Yang Bai,2 Wen Li,1 Juan Zhang,2 Xianhua Wang,4 Shihui Fu,5,6 Haiyan Zhu2
1Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Emergency, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 3Medical Innovation Research Department of PLA General Hospital, Beijing, 100853, People’s Republic of China; 4Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, People’s Republic of China; 5Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, 572013, People’s Republic of China; 6Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Haiyan Zhu, 28th Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China, Email xiaoyanzibj301@163.com Shihui Fu, 80th Jianglin Road, Haitang District, Sanya, 572013, People’s Republic of China, Email xiaoxiao0915@126.com
Purpose: Treatment of bacterial-infected diabetic wounds is still challenging due to the susceptibility to bacterial infection and oxidative stress. Therefore, a novel multifunctional platform was established for accelerating the healing of bacterial-infected diabetic wounds.
Methods: PtPdNi trimetallic-doped MIL-88 (PPNM) was fabricated and anchored to polyvinyl alcohol/sodium alginate (PVA/SA) matrix for constructing PPNM-containing hydrogel (PPNM-Gel). The basic properties of PPNM were characterized by TEM, SEM, XPS, FT-IR spectra, and UV-vis spectra. Adhesive, swelling, and degradation properties of PPNM-Gel were also analyzed. In vitro biocompatibility of PPNM-Gel was determined using L929 and HUVEC-SV40 cells. In vitro antimicrobial effects of PPNM-Gel were evaluated with E. coli and S. aureus. In vivo antibacterial and wound healing evaluation of PPNM-Gel was performed in the STZ-induced diabetic SD rats, which were established by intraperitoneal injection of STZ, followed by full-thickness skin wound preparation and bacterial infection. Histological and immunofluorescence staining were used to evaluate the status of epithelization, collagen deposition and inflammation response.
Results: PPNM exhibited multienzyme-like activity including POD-like, OXD-like, CAT-like, SOD-like, and NAD-like activities. PPNM-Gel demonstrated excellent tissue adhesive activity, water absorption ability, biodegradability, and biocompatibility. In vitro testing, PPNM-Gel showed obvious antibacterial ability against E. coli and S. aureus in a PPNM dose-dependent approach, and its antibacterial ability against E. coli was stronger than that against S. aureus. In the STZ-induced diabetic SD rats, PPNM-Gel effectively accelerated wound remodeling by killing pathogenic bacteria, reducing inflammation, and promoting collagen deposition.
Conclusion: PPNM-Gel significantly accelerated the healing of bacterial-infected diabetic wounds in the rat model. Therefore, PPNM-Gel showed great promise for the treatment of diseases affected by bacterial infections and high ROS levels.
Keywords: trimetallic nanozyme, multienzyme-like activity, hydrogel, bacterial-infected diabetic wounds
1Medical School of Chinese PLA, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Emergency, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 3Medical Innovation Research Department of PLA General Hospital, Beijing, 100853, People’s Republic of China; 4Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, People’s Republic of China; 5Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, 572013, People’s Republic of China; 6Department of Geriatric Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Haiyan Zhu, 28th Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China, Email xiaoyanzibj301@163.com Shihui Fu, 80th Jianglin Road, Haitang District, Sanya, 572013, People’s Republic of China, Email xiaoxiao0915@126.com
Purpose: Treatment of bacterial-infected diabetic wounds is still challenging due to the susceptibility to bacterial infection and oxidative stress. Therefore, a novel multifunctional platform was established for accelerating the healing of bacterial-infected diabetic wounds.
Methods: PtPdNi trimetallic-doped MIL-88 (PPNM) was fabricated and anchored to polyvinyl alcohol/sodium alginate (PVA/SA) matrix for constructing PPNM-containing hydrogel (PPNM-Gel). The basic properties of PPNM were characterized by TEM, SEM, XPS, FT-IR spectra, and UV-vis spectra. Adhesive, swelling, and degradation properties of PPNM-Gel were also analyzed. In vitro biocompatibility of PPNM-Gel was determined using L929 and HUVEC-SV40 cells. In vitro antimicrobial effects of PPNM-Gel were evaluated with E. coli and S. aureus. In vivo antibacterial and wound healing evaluation of PPNM-Gel was performed in the STZ-induced diabetic SD rats, which were established by intraperitoneal injection of STZ, followed by full-thickness skin wound preparation and bacterial infection. Histological and immunofluorescence staining were used to evaluate the status of epithelization, collagen deposition and inflammation response.
Results: PPNM exhibited multienzyme-like activity including POD-like, OXD-like, CAT-like, SOD-like, and NAD-like activities. PPNM-Gel demonstrated excellent tissue adhesive activity, water absorption ability, biodegradability, and biocompatibility. In vitro testing, PPNM-Gel showed obvious antibacterial ability against E. coli and S. aureus in a PPNM dose-dependent approach, and its antibacterial ability against E. coli was stronger than that against S. aureus. In the STZ-induced diabetic SD rats, PPNM-Gel effectively accelerated wound remodeling by killing pathogenic bacteria, reducing inflammation, and promoting collagen deposition.
Conclusion: PPNM-Gel significantly accelerated the healing of bacterial-infected diabetic wounds in the rat model. Therefore, PPNM-Gel showed great promise for the treatment of diseases affected by bacterial infections and high ROS levels.
Keywords: trimetallic nanozyme, multienzyme-like activity, hydrogel, bacterial-infected diabetic wounds