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已发表论文
儿童亚急性坏死性淋巴结炎复发的危险因素分析
Authors Wu Y, Wen Y, Long Y, Chen Y, Ding Y
Received 13 March 2025
Accepted for publication 17 September 2025
Published 10 October 2025 Volume 2025:18 Pages 14161—14170
DOI https://doi.org/10.2147/JIR.S527982
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Ning Quan
Yali Wu,1,* Yini Wen,1,* Yuan Long,2,* Yujun Chen,3 Yan Ding1
1Department of Rheumatology and Immunology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China; 2Department of Emergency, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China; 3Department of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Ding, Department of Rheumatology and Immunology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China, Email dingyanmx@163.com Yujun Chen, Department of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China, Email cyjyj2005@163.com
Objective: To analyze the clinical features of subacute necrotizing lymphadenitis (SNL) in children and to explore the risk factors for recurrence.
Methods: A retrospective case–control method was used to analyze 91 children with SNL admitted to Wuhan Children’s Hospital from June 2016 to December 2024. A total of 91 children diagnosed with SNL were included, including 8 cases with recurrence and 83 without recurrence. Sixty-seven of the 91 children with SNL included underwent lymph node pathology, and 24 did not undergo lymph node biopsy. The 91 clinically diagnosed SNL patients were divided into a recurrence group and a non-recurrence group. The 67 SNL cases that underwent lymph node pathological examination were also divided into recurrence and non-recurrence groups. Baseline information, clinical manifestations, and laboratory data were compared between the two groups, and univariate analysis was performed on the difference indicators. Binary logistic regression analysis was then used to explore the risk factors for recurrent SNL.
Results: Analyze of 91 SNL patients revealed significant differences in age at onset (p=0.032), fever duration (p=0.01), IL-4 (p=0.037), and complement C3 (p=0.01) levels between recurrent and non-recurrent groups. Multivariate analysis identified older age (OR=1.32, CI: 1.04– 1.69, p=0.025) and elevated complement C3 (OR=41.96, CI: 1.68– 1049.04, p=0.023) as independent recurrence risk factors. In a distinct cohort of 67 children with pathologically confirmed SNL, significant differences emerged between recurrent and non-recurrent cases for age (p=0.023), fever duration (p=0.027), IL-4 (p=0.012), complement C3 (p=0.023), and serum creatinine (p=0.043). Here, multivariate analysis demonstrated that elevated complement C3 (OR=45.23, CI: 1.46– 1402.72, p=0.030) at diagnosis was an independent risk factor for recurrence.
Conclusion: Older age of onset and elevated complement C3 may be risk factors for recurrence of SNL, with particular attention to elevated complement C3, and clinical follow-up is needed for this group of children.
Keywords: subacute necrotizing lymphadenitis, recurrence, risk factor
1Department of Rheumatology and Immunology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China; 2Department of Emergency, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China; 3Department of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan Ding, Department of Rheumatology and Immunology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China, Email dingyanmx@163.com Yujun Chen, Department of Pharmacy, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China, Email cyjyj2005@163.com
Objective: To analyze the clinical features of subacute necrotizing lymphadenitis (SNL) in children and to explore the risk factors for recurrence.
Methods: A retrospective case–control method was used to analyze 91 children with SNL admitted to Wuhan Children’s Hospital from June 2016 to December 2024. A total of 91 children diagnosed with SNL were included, including 8 cases with recurrence and 83 without recurrence. Sixty-seven of the 91 children with SNL included underwent lymph node pathology, and 24 did not undergo lymph node biopsy. The 91 clinically diagnosed SNL patients were divided into a recurrence group and a non-recurrence group. The 67 SNL cases that underwent lymph node pathological examination were also divided into recurrence and non-recurrence groups. Baseline information, clinical manifestations, and laboratory data were compared between the two groups, and univariate analysis was performed on the difference indicators. Binary logistic regression analysis was then used to explore the risk factors for recurrent SNL.
Results: Analyze of 91 SNL patients revealed significant differences in age at onset (p=0.032), fever duration (p=0.01), IL-4 (p=0.037), and complement C3 (p=0.01) levels between recurrent and non-recurrent groups. Multivariate analysis identified older age (OR=1.32, CI: 1.04– 1.69, p=0.025) and elevated complement C3 (OR=41.96, CI: 1.68– 1049.04, p=0.023) as independent recurrence risk factors. In a distinct cohort of 67 children with pathologically confirmed SNL, significant differences emerged between recurrent and non-recurrent cases for age (p=0.023), fever duration (p=0.027), IL-4 (p=0.012), complement C3 (p=0.023), and serum creatinine (p=0.043). Here, multivariate analysis demonstrated that elevated complement C3 (OR=45.23, CI: 1.46– 1402.72, p=0.030) at diagnosis was an independent risk factor for recurrence.
Conclusion: Older age of onset and elevated complement C3 may be risk factors for recurrence of SNL, with particular attention to elevated complement C3, and clinical follow-up is needed for this group of children.
Keywords: subacute necrotizing lymphadenitis, recurrence, risk factor