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已发表论文
流行饮食（低热量饮食、素食和无麸质饮食）与炎症性皮肤病之间的因果关系：一项孟德尔随机化研究
Authors Yu Y , Wang S, Lin J, Wu Z, Zhang Y, Wang R, Wang H
Received 6 May 2025
Accepted for publication 11 September 2025
Published 10 October 2025 Volume 2025:18 Pages 2605—2615
DOI https://doi.org/10.2147/CCID.S538761
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 6
Editor who approved publication: Dr Michela Starace
Yan Yu,1,* Shu Wang,2,* Jinru Lin,1,* Zijun Wu,1 Yiming Zhang,3 Ruijing Wang,1 Huiping Wang1
1Department of Dermatovenereology, Tianjin Medical University General Hospital/Tianjin Institute of Sexually Transmitted Disease, Tianjin, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Department of Dermatovenereology, The Second Hospital of Shandong University, Jinan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huiping Wang, Department of Dermatovenereology, Tianjin Medical University General Hospital/Tianjin Institute of Sexually Transmitted Disease, Tianjin, People’s Republic of China, Email huiping1208@163.com
Background: Inflammatory skin diseases including acne, atopic dermatitis, psoriasis, and psoriatic arthritis, and have become a major global public health concern. Diet’s impact on inflammatory skin diseases has attracted significant attention. This study utilised the Mendelian randomization (MR) method to investigate the relationship between popular diets, such as low-calorie, vegetarian, and gluten-free diets, and several common inflammatory skin diseases.
Methods: Our study employed five MR methods, including the inverse variance weighted (IVW), MR-Egger, simple mode, weighted median, and weighted mode. Sensitivity analysis was conducted to confirm the accuracy and reliability of the research findings.
Results: The results revealed a positive causal relationship between low-calorie diets and the risk of psoriatic arthritis (odds ratio [OR]: 1.05; 95% confidence interval [CI]: 1.01– 1.10; p = 0.008) but no significant association with other diseases. No significant association was observed between vegetarian or gluten-free diets and the diseases. The reliability of the conclusion was further validated through the MR-Egger regression, MR-PRESSO analysis.
Conclusion: This study offers preliminary insights into the links between diet and inflammatory skin conditions, with future large-scale, multi-method research needed to validate these findings and inform dietary recommendations.
Keywords: inflammatory skin diseases, low-calorie, vegetarian, gluten-free, Mendelian randomization
1Department of Dermatovenereology, Tianjin Medical University General Hospital/Tianjin Institute of Sexually Transmitted Disease, Tianjin, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Department of Dermatovenereology, The Second Hospital of Shandong University, Jinan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Huiping Wang, Department of Dermatovenereology, Tianjin Medical University General Hospital/Tianjin Institute of Sexually Transmitted Disease, Tianjin, People’s Republic of China, Email huiping1208@163.com
Background: Inflammatory skin diseases including acne, atopic dermatitis, psoriasis, and psoriatic arthritis, and have become a major global public health concern. Diet’s impact on inflammatory skin diseases has attracted significant attention. This study utilised the Mendelian randomization (MR) method to investigate the relationship between popular diets, such as low-calorie, vegetarian, and gluten-free diets, and several common inflammatory skin diseases.
Methods: Our study employed five MR methods, including the inverse variance weighted (IVW), MR-Egger, simple mode, weighted median, and weighted mode. Sensitivity analysis was conducted to confirm the accuracy and reliability of the research findings.
Results: The results revealed a positive causal relationship between low-calorie diets and the risk of psoriatic arthritis (odds ratio [OR]: 1.05; 95% confidence interval [CI]: 1.01– 1.10; p = 0.008) but no significant association with other diseases. No significant association was observed between vegetarian or gluten-free diets and the diseases. The reliability of the conclusion was further validated through the MR-Egger regression, MR-PRESSO analysis.
Conclusion: This study offers preliminary insights into the links between diet and inflammatory skin conditions, with future large-scale, multi-method research needed to validate these findings and inform dietary recommendations.
Keywords: inflammatory skin diseases, low-calorie, vegetarian, gluten-free, Mendelian randomization