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已发表论文
银屑病局部治疗药物递送系统的研究进展
Authors Liu Y , Chang R, Deng H, Liang F, Xu X, Luo Y
Received 7 April 2025
Accepted for publication 15 August 2025
Published 11 October 2025 Volume 2025:20 Pages 12307—12329
DOI https://doi.org/10.2147/IJN.S529899
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Dongwoo Khang
Yang Liu,1,* Ruizhen Chang,2,* Huan Deng,2 Feiqing Liang,2 Xi Xu,2 Yuning Luo2
1Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of China; 2Shenzhen Longgang Second People’s Hospital, Shenzhen, Guangdong, 518112, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xi Xu, Shenzhen Longgang Second People’s Hospital, Shenzhen, Guangdong, 518112, People’s Republic of China, Email scallet_xu@163.com Yuning Luo, Shenzhen Longgang Second People’s Hospital, Shenzhen, Guangdong, 518112, People’s Republic of China, Email 13298659917@163.com
Abstract: Psoriasis (PSO) is an immune-related skin disease featured by rapid and excessive cell growth leading to thick red scaly skin plaques. The main treatment strategy for PSO involves using anti-inflammatory drugs, immunosuppressants, etc, to relieve symptoms, suppress inflammation, and retard the overgrowth and division of skin cells. However, these drugs generally have disadvantages such as poor targeting, short half-life, low bioavailability, significant toxic side effects, etc. which impose a huge physiological and pathological burden on patients. Recently, the use of delivery systems to topical deliver drugs to the damaged psoriatic skin sites has received extensive attention from researchers. These systems promote drug stability, enhance drug penetration, and improve drug efficacies. The continuous development of various multifunctional topical delivery systems provides more therapeutic ideas for the cure of PSO. Based on this, this manuscript reviews the research progress of various delivery systems (including nanoparticles, hydrogels, microneedles, micelles, dendrimers, liposomes, nanoemulsions, vesicles, etc.) for PSO topical therapy and summarizes their development status in clinical treatment. It’s expected to provide reference for the design of novel topical delivery systems and promote the development of PSO therapy methods.
Keywords: psoriasis, drug carrier, drug delivery, topical therapy
1Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of China; 2Shenzhen Longgang Second People’s Hospital, Shenzhen, Guangdong, 518112, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xi Xu, Shenzhen Longgang Second People’s Hospital, Shenzhen, Guangdong, 518112, People’s Republic of China, Email scallet_xu@163.com Yuning Luo, Shenzhen Longgang Second People’s Hospital, Shenzhen, Guangdong, 518112, People’s Republic of China, Email 13298659917@163.com
Abstract: Psoriasis (PSO) is an immune-related skin disease featured by rapid and excessive cell growth leading to thick red scaly skin plaques. The main treatment strategy for PSO involves using anti-inflammatory drugs, immunosuppressants, etc, to relieve symptoms, suppress inflammation, and retard the overgrowth and division of skin cells. However, these drugs generally have disadvantages such as poor targeting, short half-life, low bioavailability, significant toxic side effects, etc. which impose a huge physiological and pathological burden on patients. Recently, the use of delivery systems to topical deliver drugs to the damaged psoriatic skin sites has received extensive attention from researchers. These systems promote drug stability, enhance drug penetration, and improve drug efficacies. The continuous development of various multifunctional topical delivery systems provides more therapeutic ideas for the cure of PSO. Based on this, this manuscript reviews the research progress of various delivery systems (including nanoparticles, hydrogels, microneedles, micelles, dendrimers, liposomes, nanoemulsions, vesicles, etc.) for PSO topical therapy and summarizes their development status in clinical treatment. It’s expected to provide reference for the design of novel topical delivery systems and promote the development of PSO therapy methods.
Keywords: psoriasis, drug carrier, drug delivery, topical therapy