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已发表论文
0.25%罗哌卡因用于开胸心脏手术患者双侧胸横肌平面阻滞的中位有效容量
Authors Sun J , Liu C , Gong X , Chen R , Deng S, Zha Y, Ji S, Jin Z, Chen H
Received 12 May 2025
Accepted for publication 8 September 2025
Published 11 October 2025 Volume 2025:18 Pages 5321—5329
DOI https://doi.org/10.2147/JPR.S537002
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jinlei Li
Jiaying Sun,1,2,* Chufan Liu,1,* Xinlian Gong,1 Ruoxing Chen,1 Shikang Deng,3 Yujun Zha,1 Shijie Ji,1 Zhousheng Jin,1 Hongfei Chen1
1Department of Pain Management, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang, People’s Republic of China; 2Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, People’s Republic of China; 3Ruian Tangxia People’s Hospital, Ruian, Wenzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hongfei Chen, Department of Pain Management, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325013, People’s Republic of China, Email chhfei@126.com
Background: The median effective dose of ropivacaine required to achieve an effective transversus thoracis muscle plane block (TTP) has not been established. This study aimed to determine the EV50 of 0.25% ropivacaine for TTP using Dixon’s up-and-down method.
Methods: This prospective study involved 21 patients with American Society of Anesthesiologists physical status II to III, aged 20 to 60 years, with a BMI of 18 to 30 kg/m², who were scheduled for open cardiac surgery. Bilateral TTP was performed preoperatively, and 30 minutes post-block, the cold sensory decrease area (CSDA) was marked and recorded. The initial volume of 0.25% ropivacaine administered was 20mL. The effective block was defined as the CSDA encompassing thoracic nerves 2 to 6, which dictated a 2 mL increment or decrement in the subsequent patient’s dosage. The study concluded when volumes reached 5 mL or 40 mL for 7 patients, or after 7 turning points.
Results: A total of 21 cases were evaluated. Twelve (57.1%) of 40 received an effective block, while nine (42.9%) patients received a non-effective block. Analysis using SPSS 26.0 revealed the median effective volume (EV50) of 16.36mL for 0.25% ropivacaine and the 95% effective volume (EV95) of 19.81mL.
Conclusion: In open cardiac surgery, the median effective volume of 0.25% ropivacaine for TTP is 16.36 mL (95% CI 14.35 to 18.43), while the 95% effective volume is 19.81 mL (95% CI 18.60 to 22.75).
Trial Registration Number: ChiCTR2300073449.
Keywords: regional anesthesia, cardiac surgical procedures, sternotomy, pain management
1Department of Pain Management, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang, People’s Republic of China; 2Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, People’s Republic of China; 3Ruian Tangxia People’s Hospital, Ruian, Wenzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hongfei Chen, Department of Pain Management, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325013, People’s Republic of China, Email chhfei@126.com
Background: The median effective dose of ropivacaine required to achieve an effective transversus thoracis muscle plane block (TTP) has not been established. This study aimed to determine the EV50 of 0.25% ropivacaine for TTP using Dixon’s up-and-down method.
Methods: This prospective study involved 21 patients with American Society of Anesthesiologists physical status II to III, aged 20 to 60 years, with a BMI of 18 to 30 kg/m², who were scheduled for open cardiac surgery. Bilateral TTP was performed preoperatively, and 30 minutes post-block, the cold sensory decrease area (CSDA) was marked and recorded. The initial volume of 0.25% ropivacaine administered was 20mL. The effective block was defined as the CSDA encompassing thoracic nerves 2 to 6, which dictated a 2 mL increment or decrement in the subsequent patient’s dosage. The study concluded when volumes reached 5 mL or 40 mL for 7 patients, or after 7 turning points.
Results: A total of 21 cases were evaluated. Twelve (57.1%) of 40 received an effective block, while nine (42.9%) patients received a non-effective block. Analysis using SPSS 26.0 revealed the median effective volume (EV50) of 16.36mL for 0.25% ropivacaine and the 95% effective volume (EV95) of 19.81mL.
Conclusion: In open cardiac surgery, the median effective volume of 0.25% ropivacaine for TTP is 16.36 mL (95% CI 14.35 to 18.43), while the 95% effective volume is 19.81 mL (95% CI 18.60 to 22.75).
Trial Registration Number: ChiCTR2300073449.
Keywords: regional anesthesia, cardiac surgical procedures, sternotomy, pain management