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已发表论文
孤立性胸锁关节髓外浆细胞瘤一例：罕见病例报告
Authors Yan Y, Ouyang M, Han Y
Received 8 July 2025
Accepted for publication 2 October 2025
Published 11 October 2025 Volume 2025:18 Pages 14175—14184
DOI https://doi.org/10.2147/JIR.S548136
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Subhasis Chattopadhyay
Yiwei Yan,1 Mingli Ouyang,2 Yongmei Han2
1Department of Rheumatology, Shaoxing Shangyu District Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang Province, 312300, People’s Republic of China; 2Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310016, People’s Republic of China
Correspondence: Yongmei Han, Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou City, Zhejiang Province, 310016, People’s Republic of China, Email 3408235@zju.edu.cn
Background: Solitary extramedullary plasmacytoma (SEP) is a rare proliferative clonal plasma cell disease. However, its occurrence in the sternoclavicular joint region has not yet been reported. Owing to the complex anatomical structure of this area and the lack of specific clinical manifestations, early diagnosis is challenging, and it is often misdiagnosed as other common bone and joint diseases.
Case Presentation: We present the case of a 62-year-old male patient with a 2-month history of progressive swelling and pain in the left sternoclavicular joint. Upon admission, elevated levels of inflammatory markers were observed. Blood Next-Generation Sequencing (NGS) indicated the presence of Pseudomonas, and the soft tissue culture of the sternoclavicular joint revealed the presence of Pseudomonas aeruginosa and Proteus mirabilis. Due to poor response to anti-infectious and anti-inflammatory treatments, malignancy could not be excluded. Biopsy was performed, the lesion was resected by thoracoscopy, and SEP was confirmed by pathological examination. The patient underwent local post-operative radiotherapy. After nine-months of follow-up, the patient’s joint pain resolved.
Conclusion: Sternoclavicular joint swelling and pain are observed in spondyloarthritis, SAPHO syndrome, infections, and tumors. Involvement of the sternoclavicular joint by SEP has rarely been reported. Timely pathological examinations are crucial for patients with an unclear diagnosis. Given that SEP may progress to multiple myeloma (MM) within five years, early diagnosis and timely intervention are critically important.
Keywords: solitary extramedullary plasmacytoma, sternoclavicular joint, multiple myeloma, solitary bone plasmacytoma, SAPHO syndrome
1Department of Rheumatology, Shaoxing Shangyu District Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang Province, 312300, People’s Republic of China; 2Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310016, People’s Republic of China
Correspondence: Yongmei Han, Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3, Qingchun East Road, Shangcheng District, Hangzhou City, Zhejiang Province, 310016, People’s Republic of China, Email 3408235@zju.edu.cn
Background: Solitary extramedullary plasmacytoma (SEP) is a rare proliferative clonal plasma cell disease. However, its occurrence in the sternoclavicular joint region has not yet been reported. Owing to the complex anatomical structure of this area and the lack of specific clinical manifestations, early diagnosis is challenging, and it is often misdiagnosed as other common bone and joint diseases.
Case Presentation: We present the case of a 62-year-old male patient with a 2-month history of progressive swelling and pain in the left sternoclavicular joint. Upon admission, elevated levels of inflammatory markers were observed. Blood Next-Generation Sequencing (NGS) indicated the presence of Pseudomonas, and the soft tissue culture of the sternoclavicular joint revealed the presence of Pseudomonas aeruginosa and Proteus mirabilis. Due to poor response to anti-infectious and anti-inflammatory treatments, malignancy could not be excluded. Biopsy was performed, the lesion was resected by thoracoscopy, and SEP was confirmed by pathological examination. The patient underwent local post-operative radiotherapy. After nine-months of follow-up, the patient’s joint pain resolved.
Conclusion: Sternoclavicular joint swelling and pain are observed in spondyloarthritis, SAPHO syndrome, infections, and tumors. Involvement of the sternoclavicular joint by SEP has rarely been reported. Timely pathological examinations are crucial for patients with an unclear diagnosis. Given that SEP may progress to multiple myeloma (MM) within five years, early diagnosis and timely intervention are critically important.
Keywords: solitary extramedullary plasmacytoma, sternoclavicular joint, multiple myeloma, solitary bone plasmacytoma, SAPHO syndrome