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已发表论文
新发现的植物源类外泌体颗粒的关键治疗价值：证据综合综述
Authors Chi J , Wang X, Song Y, Wang J, Guo L, Wang R, Wang G
Received 31 May 2025
Accepted for publication 25 September 2025
Published 12 October 2025 Volume 2025:20 Pages 12393—12411
DOI https://doi.org/10.2147/IJN.S543947
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Farooq A. Shiekh
Jia Chi,1,* Xubo Wang,1,* Yanrui Song,1 Jiazhi Wang,1 Lin Guo,1 Rui Wang,2,3 Guangzhi Wang1
1Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, People’s Republic of China; 2Department of Oncology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430065, People’s Republic of China; 3Department of Oncology, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, 430061, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Rui Wang, Department of Oncology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430065, People’s Republic of China, Email 20961691@qq.com Guangzhi Wang, Department of General Surgery, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian, Liaoning, 116023, People’s Republic of China, Tel +86-411-84671291-5277, Email wanggz@dmu.edu.cn
Abstract: Plant-derived exosome-like nanoparticles (PELNs) are lipid bilayer-enclosed nanoscale vesicles isolated from plant cells, harboring a diverse cargo such as RNAs, proteins, lipids, and biologically active constituents. Increasing evidence indicates that PELNs can efficiently enter mammalian cells through multiple uptake pathways, including phagocytosis, clathrin/caveolin-mediated endocytosis, and macropinocytosis. In recent years, they have emerged as highly promising nanocarriers for targeted drug delivery, disease diagnosis, and therapeutic intervention. This review provides a systematic overview of the therapeutic applications of PELNs across various diseases and the signaling mechanisms involved, while briefly outlining their isolation and characterization to provide essential research background. Despite remarkable advancements, the field still has several challenges, including protocol standardization, precise marker identification, biological stability, and refinement of targeted delivery strategies. Nevertheless, owing to their intrinsic properties, such as low cytotoxicity, high biocompatibility, inherent targeting capacity, minimal immunogenicity, and surface modifiability, PELNs hold considerable promise as next-generation delivery vectors. Future investigations will likely focus on refining manufacturing processes, elucidating PELN-associated molecular mechanisms, and engineering more advanced delivery systems designed for clinical translation.
Keywords: plant-derived exosome-like nanoparticles, extracellular vesicles, drug delivery, signal transduction pathways, therapeutic applications
1Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, People’s Republic of China; 2Department of Oncology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430065, People’s Republic of China; 3Department of Oncology, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, 430061, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Rui Wang, Department of Oncology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430065, People’s Republic of China, Email 20961691@qq.com Guangzhi Wang, Department of General Surgery, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian, Liaoning, 116023, People’s Republic of China, Tel +86-411-84671291-5277, Email wanggz@dmu.edu.cn
Abstract: Plant-derived exosome-like nanoparticles (PELNs) are lipid bilayer-enclosed nanoscale vesicles isolated from plant cells, harboring a diverse cargo such as RNAs, proteins, lipids, and biologically active constituents. Increasing evidence indicates that PELNs can efficiently enter mammalian cells through multiple uptake pathways, including phagocytosis, clathrin/caveolin-mediated endocytosis, and macropinocytosis. In recent years, they have emerged as highly promising nanocarriers for targeted drug delivery, disease diagnosis, and therapeutic intervention. This review provides a systematic overview of the therapeutic applications of PELNs across various diseases and the signaling mechanisms involved, while briefly outlining their isolation and characterization to provide essential research background. Despite remarkable advancements, the field still has several challenges, including protocol standardization, precise marker identification, biological stability, and refinement of targeted delivery strategies. Nevertheless, owing to their intrinsic properties, such as low cytotoxicity, high biocompatibility, inherent targeting capacity, minimal immunogenicity, and surface modifiability, PELNs hold considerable promise as next-generation delivery vectors. Future investigations will likely focus on refining manufacturing processes, elucidating PELN-associated molecular mechanisms, and engineering more advanced delivery systems designed for clinical translation.
Keywords: plant-derived exosome-like nanoparticles, extracellular vesicles, drug delivery, signal transduction pathways, therapeutic applications