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已发表论文
一名感染 HIV 的患者在接受抗逆转录病毒治疗后出现免疫重建炎症综合征，并被诊断为原发性免疫性血小板减少症、成人隐匿性自身免疫糖尿病以及桥本甲状腺炎：病例报告及文献综述
Authors Yu L, Zhang B, Wan H, Ying H, Qian X
Received 16 April 2025
Accepted for publication 20 September 2025
Published 13 October 2025 Volume 2025:18 Pages 5315—5321
DOI https://doi.org/10.2147/IDR.S534912
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Héctor Mora-Montes
Lele Yu,1 Binhai Zhang,1 Hu Wan,1 Huimin Ying,2 Xiaolu Qian2
1Department II of Infectious Diseases, Hangzhou Xixi Hospital, Hangzhou Sixth People’s Hospital, Hangzhou, Zhejiang, 310023, People’s Republic of China; 2Department of Endocrinology, Hangzhou Xixi Hospital, Hangzhou Sixth People’s Hospital, Hangzhou, Zhejiang, 310023, People’s Republic of China
Correspondence: Xiaolu Qian, Email QIANWANGLU11@163.com
Introduction: Immune reconstitution inflammatory syndrome (IRIS) is closely associated with antiretroviral therapy (ART) and poses a clinical challenge in HIV management.
Case Presentation: This report describes an HIV-infected individual who developed Primary immune thrombocytopenia, latent autoimmune diabetes in adults, and Hashimoto thyroiditis after starting ART.
Conclusion: Antiretroviral therapy (ART) may result in thrombocytopenia, fluctuations in blood glucose levels, thyroid dysfunction, diabetic ketoacidosis (DKA), or thyroid crisis. Healthcare professionals should evaluate the potential links between immune reconstitution inflammatory syndrome (IRIS) and latent autoimmune diabetes in adults (LADA), immune thrombocytopenia (ITP), as well as Hashimoto thyroiditis (HT).
Keywords: HIV, IRIS, LADA, case report
1Department II of Infectious Diseases, Hangzhou Xixi Hospital, Hangzhou Sixth People’s Hospital, Hangzhou, Zhejiang, 310023, People’s Republic of China; 2Department of Endocrinology, Hangzhou Xixi Hospital, Hangzhou Sixth People’s Hospital, Hangzhou, Zhejiang, 310023, People’s Republic of China
Correspondence: Xiaolu Qian, Email QIANWANGLU11@163.com
Introduction: Immune reconstitution inflammatory syndrome (IRIS) is closely associated with antiretroviral therapy (ART) and poses a clinical challenge in HIV management.
Case Presentation: This report describes an HIV-infected individual who developed Primary immune thrombocytopenia, latent autoimmune diabetes in adults, and Hashimoto thyroiditis after starting ART.
Conclusion: Antiretroviral therapy (ART) may result in thrombocytopenia, fluctuations in blood glucose levels, thyroid dysfunction, diabetic ketoacidosis (DKA), or thyroid crisis. Healthcare professionals should evaluate the potential links between immune reconstitution inflammatory syndrome (IRIS) and latent autoimmune diabetes in adults (LADA), immune thrombocytopenia (ITP), as well as Hashimoto thyroiditis (HT).
Keywords: HIV, IRIS, LADA, case report