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已发表论文
1992 年至 2021 年全球、区域及各国育龄期（15 至 49 岁）女性炎症性肠病的疾病负担
Authors Zhang Z , Jia SW, Xu CM, Chen W, Du N , Sun T, Chen TT, Xiao Y
Received 25 May 2025
Accepted for publication 9 October 2025
Published 13 October 2025 Volume 2025:17 Pages 3667—3681
DOI https://doi.org/10.2147/IJWH.S542666
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Matteo Frigerio
Zhou Zhang,1,* Shu-Wan Jia,1,* Chun-Mei Xu,1 Wei Chen,1 Na Du,2 Ting Sun,1 Ting-Ting Chen,3 Yu Xiao4
1Department of Gastroenterology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China; 2Psychosomatic Medical Center, The Fourth People’s Hospital of Chengdu, Chengdu, 610036, People’s Republic of China; 3Mental Health Center, West China Hospital of Sichuan University, Chengdu, 610041, People’s Republic of China; 4Department of Psychosomatic Medicine, Chengdu Fifth People’s Hospital, Chengdu, 611130, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yu Xiao, Chengdu Fifth People’s Hospital, No. 33, Mashi Street, Wenjiang District, Chengdu, Sichuan, 611130, People’s Republic of China, Email xiaoy3@outlook.com
Background: Inflammatory bowel disease (IBD) substantially affects women of reproductive age, yet global trends and burdens within this group remain inadequately explored. This study evaluates the global, regional, and national burdens of IBD among women aged 15– 49 from 1992 to 2021, with projections to 2030.
Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 study. We analyzed incidence, mortality, and disability-adjusted life years (DALYs) of IBD across age groups. Trends over time were assessed using estimated annual percentage change (EAPC), and socio-demographic index (SDI) levels were applied to examine disparities related to development status.
Results: In 2021, the global IBD cases among women aged 15– 49 reached 98,974.56, representing a 55.04% increase since 1992. Mortality remained relatively stable, with 2,586.76 deaths in 2021, while DALYs rose by 38.53% to 281,580.36. High SDI regions exhibited higher incidence and DALYs rates but lower mortality rates. Conversely, low and middle SDI regions faced greater challenges, with higher mortality and DALYs rates despite lower incidence rates. By 2030, projections suggest a slight decline in global incidence rates, reducing total cases to approximately 94,773. Mortality rates are anticipated to remain stable, though deaths may slightly increase to 2781. DALYs are projected to rise marginally to 284,508 by 2030.
Conclusion: The global burden of IBD among women of reproductive age has markedly increased, displaying considerable regional and socio-demographic variations. Targeted public health strategies are crucial, particularly in regions with lower development levels.
Keywords: inflammatory bowel disease, women of reproductive age, global burden, epidemiology, socio-demographic index
1Department of Gastroenterology, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, 441000, People’s Republic of China; 2Psychosomatic Medical Center, The Fourth People’s Hospital of Chengdu, Chengdu, 610036, People’s Republic of China; 3Mental Health Center, West China Hospital of Sichuan University, Chengdu, 610041, People’s Republic of China; 4Department of Psychosomatic Medicine, Chengdu Fifth People’s Hospital, Chengdu, 611130, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yu Xiao, Chengdu Fifth People’s Hospital, No. 33, Mashi Street, Wenjiang District, Chengdu, Sichuan, 611130, People’s Republic of China, Email xiaoy3@outlook.com
Background: Inflammatory bowel disease (IBD) substantially affects women of reproductive age, yet global trends and burdens within this group remain inadequately explored. This study evaluates the global, regional, and national burdens of IBD among women aged 15– 49 from 1992 to 2021, with projections to 2030.
Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 study. We analyzed incidence, mortality, and disability-adjusted life years (DALYs) of IBD across age groups. Trends over time were assessed using estimated annual percentage change (EAPC), and socio-demographic index (SDI) levels were applied to examine disparities related to development status.
Results: In 2021, the global IBD cases among women aged 15– 49 reached 98,974.56, representing a 55.04% increase since 1992. Mortality remained relatively stable, with 2,586.76 deaths in 2021, while DALYs rose by 38.53% to 281,580.36. High SDI regions exhibited higher incidence and DALYs rates but lower mortality rates. Conversely, low and middle SDI regions faced greater challenges, with higher mortality and DALYs rates despite lower incidence rates. By 2030, projections suggest a slight decline in global incidence rates, reducing total cases to approximately 94,773. Mortality rates are anticipated to remain stable, though deaths may slightly increase to 2781. DALYs are projected to rise marginally to 284,508 by 2030.
Conclusion: The global burden of IBD among women of reproductive age has markedly increased, displaying considerable regional and socio-demographic variations. Targeted public health strategies are crucial, particularly in regions with lower development levels.
Keywords: inflammatory bowel disease, women of reproductive age, global burden, epidemiology, socio-demographic index