109451
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
胰腺实性假乳头状瘤合并产科抗磷脂综合征的高危妊娠：一例报告
Authors Li S, Yu S, Yu X, Meng X, Zhu Y
Received 28 July 2025
Accepted for publication 2 October 2025
Published 15 October 2025 Volume 2025:17 Pages 3693—3698
DOI https://doi.org/10.2147/IJWH.S554457
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Shan Li, Shasha Yu, Xiaomei Yu, Xiangcheng Meng, Yuchun Zhu
Obstetrics Medical Center, WeiFang People’s Hospital, Shandong Second Medical University, WeiFang, People’s Republic of China
Correspondence: Yuchun Zhu, Obstetrics Medical Center, WeiFang People’s Hospital, Shandong Second Medical University, WeiFang, People’s Republic of China, Email zyc15065658122@163.com
Background: Antiphospholipid syndrome(APS) is a common cause of recurrent miscarriage.This case report presents a rare case of a high-risk pregnancy complicated by the concurrent solid pseudopapillary neoplasm (SPN) and obstetric antiphospholipid syndrome (OAPS).
Case: A 35-year-old patient was diagnosed with SPN at the age of 27, accompanied by extensive abdominal metastases, and underwent palliative metastatic tumor resection and chemotherapy, achieving stable disease. After a 24-month treatment-free interval, pregnancy was attempted. She had a history of five adverse pregnancy outcomes (one intrauterine fetal demise at 28 weeks, three instances of embryonic arrest, and one biochemical pregnancy). OAPS was diagnosed based on persistent positivity (≥ 12 weeks apart) for lupus anticoagulant, anti-β 2 glycoprotein I antibody, and anti-cardiolipin antibody. Following a multidisciplinary evaluation, she was treated with a combination of tacrolimus, hydroxychloroquine, and prednisone to control antibody levels before planning for pregnancy. During the pregnancy, low molecular weight heparin combined with aspirin was administered, and ultimately, a healthy live baby was delivered via cesarean section at 36 weeks of gestation, with favorable maternal and neonatal outcomes. Currently, the patient remains disease-free with regular oncology follow-up and has preserved ovarian function.
Conclusion: This case suggests that for patients with tumors and pathological pregnancies, screening for the presence of antiphospholipid syndrome should be emphasized. Although SPN poses risks such as tumor growth and hemorrhage during pregnancy, patients with long-term stable disease may attempt pregnancy under close monitoring. It is important to balance the risks of anticoagulation with those of tumor-related bleeding during pregnancy.
Keywords: solid pseudopapillary neoplasm, obstetric antiphospholipid syndrome, pathological pregnancies
Obstetrics Medical Center, WeiFang People’s Hospital, Shandong Second Medical University, WeiFang, People’s Republic of China
Correspondence: Yuchun Zhu, Obstetrics Medical Center, WeiFang People’s Hospital, Shandong Second Medical University, WeiFang, People’s Republic of China, Email zyc15065658122@163.com
Background: Antiphospholipid syndrome(APS) is a common cause of recurrent miscarriage.This case report presents a rare case of a high-risk pregnancy complicated by the concurrent solid pseudopapillary neoplasm (SPN) and obstetric antiphospholipid syndrome (OAPS).
Case: A 35-year-old patient was diagnosed with SPN at the age of 27, accompanied by extensive abdominal metastases, and underwent palliative metastatic tumor resection and chemotherapy, achieving stable disease. After a 24-month treatment-free interval, pregnancy was attempted. She had a history of five adverse pregnancy outcomes (one intrauterine fetal demise at 28 weeks, three instances of embryonic arrest, and one biochemical pregnancy). OAPS was diagnosed based on persistent positivity (≥ 12 weeks apart) for lupus anticoagulant, anti-β 2 glycoprotein I antibody, and anti-cardiolipin antibody. Following a multidisciplinary evaluation, she was treated with a combination of tacrolimus, hydroxychloroquine, and prednisone to control antibody levels before planning for pregnancy. During the pregnancy, low molecular weight heparin combined with aspirin was administered, and ultimately, a healthy live baby was delivered via cesarean section at 36 weeks of gestation, with favorable maternal and neonatal outcomes. Currently, the patient remains disease-free with regular oncology follow-up and has preserved ovarian function.
Conclusion: This case suggests that for patients with tumors and pathological pregnancies, screening for the presence of antiphospholipid syndrome should be emphasized. Although SPN poses risks such as tumor growth and hemorrhage during pregnancy, patients with long-term stable disease may attempt pregnancy under close monitoring. It is important to balance the risks of anticoagulation with those of tumor-related bleeding during pregnancy.
Keywords: solid pseudopapillary neoplasm, obstetric antiphospholipid syndrome, pathological pregnancies