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已发表论文
急性敌草快中毒患者早期免疫炎症特征及预后生物标志物的多中心研究：探索性生物信息学分析
Authors Wang P, Lin LY, Song CY, Fang JJ, Zhang BW, Li WS, Yu HJ, Fu YP, Lu YQ
Received 19 June 2025
Accepted for publication 3 October 2025
Published 15 October 2025 Volume 2025:18 Pages 14245—14260
DOI https://doi.org/10.2147/JIR.S547369
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Ning Quan
Ping Wang,1,2 Li-Ying Lin,1,2 Cong-Ying Song,1,2 Jian-Jiang Fang,3 Bing-Wen Zhang,4 Wan-Sheng Li,5 Hui-Jie Yu,6 Yong-Ping Fu,7 Yuan-Qiang Lu1,2
1Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of China; 2Zhejiang Key Laboratory for Diagnosis and Treatment of Physic-Chemical and Aging-Related Injuries, Hangzhou, Zhejiang, 310003, People’s Republic of China; 3Department of Emergency Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315040, People’s Republic of China; 4Department of Emergency Medicine, Jinhua Municipal Central Hospital, Jinghua, Zhejiang, 321000, People’s Republic of China; 5Department of Emergency Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang, 318000, People’s Republic of China; 6Department of Emergency Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People’s Republic of China; 7Department of Emergency Medicine, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, 312000, People’s Republic of China
Correspondence: Yuan-Qiang Lu, Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of China, Tel +86 13588706807, Email luyuanqiang@zju.edu.cn
Purpose: With the increasing incidence of acute diquat (DQ) poisoning, this study aims to analyze immune biomarkers in patients and explore their impact on outcomes.
Methods: A retrospective multicenter cohort study included 145 patients with acute DQ poisoning from six hospitals in Zhejiang Province, China. Immune-inflammatory parameters were compared between DQ patients and healthy controls. Patients were then grouped according to their 28-day survival status for prognostic analysis. Clinical, laboratory, and immune parameters were collected. Least absolute shrinkage and selection operator (LASSO) regression, multivariate logistic regression, and receiver operating characteristic analysis were used to identify predictors of mortality. Bioinformatics analysis was performed to explore potential molecular targets and pathways.
Results: Of 145 patients, 72 died within 28 days. Non-survivors showed higher procalcitonin (PCT), lactate, and organ injury markers, as well as elevated interleukin-6 and interleukin-10, compared with survivors. Compared with healthy controls, patients with DQ poisoning exhibited increased white blood cells (WBC), neutrophils, monocytes, and cytokines, alongside reduced lymphocytes and T-cell subsets (all P < 0.0001). LASSO and logistic regression identified PCT, WBC, and lactate as independent predictors of mortality, with PCT providing the greatest discriminative value (AUC = 0.88). Bioinformatics analysis further indicated enrichment of immune-related pathways and hub genes associated with immune dysregulation.
Conclusion: Acute DQ poisoning causes pronounced immune-inflammatory disturbances that are more severe in non-survivors. PCT is the strongest independent predictor of 28-day mortality, while exploratory bioinformatics highlights immune pathways with potential prognostic and therapeutic relevance.
Keywords: diquat poisoning, procalcitonin, immune-related biomarker, immune dysregulation, STAT3, bioinformatics analysis
1Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of China; 2Zhejiang Key Laboratory for Diagnosis and Treatment of Physic-Chemical and Aging-Related Injuries, Hangzhou, Zhejiang, 310003, People’s Republic of China; 3Department of Emergency Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315040, People’s Republic of China; 4Department of Emergency Medicine, Jinhua Municipal Central Hospital, Jinghua, Zhejiang, 321000, People’s Republic of China; 5Department of Emergency Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang, 318000, People’s Republic of China; 6Department of Emergency Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People’s Republic of China; 7Department of Emergency Medicine, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, 312000, People’s Republic of China
Correspondence: Yuan-Qiang Lu, Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of China, Tel +86 13588706807, Email luyuanqiang@zju.edu.cn
Purpose: With the increasing incidence of acute diquat (DQ) poisoning, this study aims to analyze immune biomarkers in patients and explore their impact on outcomes.
Methods: A retrospective multicenter cohort study included 145 patients with acute DQ poisoning from six hospitals in Zhejiang Province, China. Immune-inflammatory parameters were compared between DQ patients and healthy controls. Patients were then grouped according to their 28-day survival status for prognostic analysis. Clinical, laboratory, and immune parameters were collected. Least absolute shrinkage and selection operator (LASSO) regression, multivariate logistic regression, and receiver operating characteristic analysis were used to identify predictors of mortality. Bioinformatics analysis was performed to explore potential molecular targets and pathways.
Results: Of 145 patients, 72 died within 28 days. Non-survivors showed higher procalcitonin (PCT), lactate, and organ injury markers, as well as elevated interleukin-6 and interleukin-10, compared with survivors. Compared with healthy controls, patients with DQ poisoning exhibited increased white blood cells (WBC), neutrophils, monocytes, and cytokines, alongside reduced lymphocytes and T-cell subsets (all P < 0.0001). LASSO and logistic regression identified PCT, WBC, and lactate as independent predictors of mortality, with PCT providing the greatest discriminative value (AUC = 0.88). Bioinformatics analysis further indicated enrichment of immune-related pathways and hub genes associated with immune dysregulation.
Conclusion: Acute DQ poisoning causes pronounced immune-inflammatory disturbances that are more severe in non-survivors. PCT is the strongest independent predictor of 28-day mortality, while exploratory bioinformatics highlights immune pathways with potential prognostic and therapeutic relevance.
Keywords: diquat poisoning, procalcitonin, immune-related biomarker, immune dysregulation, STAT3, bioinformatics analysis