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已发表论文
海堂合剂治疗中度难治性酒渣鼻 1 例：身心症状全面改善的病例报告
Authors Liu X , Wang Y, Han Y, Liu Q, Guo L , Jiang X
Received 5 February 2025
Accepted for publication 8 September 2025
Published 15 October 2025 Volume 2025:18 Pages 2663—2667
DOI https://doi.org/10.2147/CCID.S518165
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Anne-Claire Fougerousse
Xu Liu,1,2,* Yu Wang,3,* Yanbing Han,4,* Qingfeng Liu,1,2 Linghong Guo,1,2 Xian Jiang1,2
1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Sichuan Hamilton Medical Cosmetology Hospital, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xian Jiang, West China Hospital, Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Tel +86-028-85423315, Fax +86-028-85422560, Email jiangxian@scu.edu.cn Linghong Guo, West China Hospital, Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Tel +86-028-85423315, Fax +86-028-85422560, Email linhom.guo@foxmail.com
Abstract: Rosacea is a chronic inflammatory skin disease that significantly impacts patients’ quality of life. Current treatments have limitations. We report a case of moderate papulopustular rosacea effectively treated with the Chinese herbal formula HaiTang Heji. A 34-year-old Asian woman with a 3-year history of recurrent facial erythema, papules, pustules, and flushing, refractory to conventional therapies, showed significant improvement after 16 weeks of HaiTang Heji 20mL tid. Investigator Global Assessment (IGA) decreased from 3 to 1, Global Flushing Severity Scale (GFSS) from 3 to 1, anxiety scores decreased from moderate to mild levels, and depression scores decreased from mild to minimal levels. The patient tolerated the treatment well with no reported adverse effects, highlighting the potential safety of this herbal formula. Response was largely maintained at 21-week follow-up. HaiTang Heji’s therapeutic mechanisms may involve anti-inflammatory, immunomodulatory, anti-angiogenic, and gut-brain-skin axis modulation. Further research is warranted to confirm its efficacy and safety as an alternative rosacea treatment.
Keywords: rosacea, HaiTang Heji, Chinese herbal medicine, Tripterygium hypoglaucum, case report, flushing, quality of life
1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Sichuan Hamilton Medical Cosmetology Hospital, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xian Jiang, West China Hospital, Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Tel +86-028-85423315, Fax +86-028-85422560, Email jiangxian@scu.edu.cn Linghong Guo, West China Hospital, Sichuan University, #37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Tel +86-028-85423315, Fax +86-028-85422560, Email linhom.guo@foxmail.com
Abstract: Rosacea is a chronic inflammatory skin disease that significantly impacts patients’ quality of life. Current treatments have limitations. We report a case of moderate papulopustular rosacea effectively treated with the Chinese herbal formula HaiTang Heji. A 34-year-old Asian woman with a 3-year history of recurrent facial erythema, papules, pustules, and flushing, refractory to conventional therapies, showed significant improvement after 16 weeks of HaiTang Heji 20mL tid. Investigator Global Assessment (IGA) decreased from 3 to 1, Global Flushing Severity Scale (GFSS) from 3 to 1, anxiety scores decreased from moderate to mild levels, and depression scores decreased from mild to minimal levels. The patient tolerated the treatment well with no reported adverse effects, highlighting the potential safety of this herbal formula. Response was largely maintained at 21-week follow-up. HaiTang Heji’s therapeutic mechanisms may involve anti-inflammatory, immunomodulatory, anti-angiogenic, and gut-brain-skin axis modulation. Further research is warranted to confirm its efficacy and safety as an alternative rosacea treatment.
Keywords: rosacea, HaiTang Heji, Chinese herbal medicine, Tripterygium hypoglaucum, case report, flushing, quality of life