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已发表论文
肝脾 CT 值、BISAP 评分联合血清 sPD-L1 对高脂血症性急性胰腺炎的预测价值
Authors Liu T, Peng L, Huo Y, Lu T, Lv X
Received 22 May 2025
Accepted for publication 21 August 2025
Published 15 October 2025 Volume 2025:18 Pages 6245—6254
DOI https://doi.org/10.2147/IJGM.S542198
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Gopal Krishna Dhali
Tao Liu,1,* Lina Peng,1,* Yifang Huo,2 Ting Lu,1 Xiaoping Lv3
1Department of Spleen, Stomach and Hepatology, Guangxi International Zhuang Medical Hospital, Nanning, Guangxi, People’s Republic of China; 2Department of Gastroenterology, Wuzhou Gongren Hospital, Wuzhou, Guangxi, People’s Republic of China; 3Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoping Lv, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, People’s Republic of China, Email prvv42@sina.com
Objective: To explore the predictive value of liver/spleen CT Value, bedside index for severity in acute pancreatitis (BISAP) score combined with serum soluble programmed death ligand 1 (sPD-L1) within 24 hours of onset for the severity tendency of hyperlipidemic acute pancreatitis (HTG-AP).
Methods: A retrospective study was conducted on the clinical data of 102 patients with mild to moderate HTG-AP. These patients were divided into the progression group (24 cases) and the stable group (78 cases) based on whether they progressed to severe HTG-AP. The liver/spleen CT values, BISAP scores, serum sPD-L1 levels and blood urea nitrogen (BUN) levels were compared within 24 hours of onset in the two groups. The COX regression model was used to analyze the influencing factors of the tendency of HTG-AP severity. The predictive efficacy of each indicator was evaluated through the Receiver operating characteristic curves (ROC).
Results: The BUN, BISAP score, serum sPD-L1 levels, and the proportion of moderate HTG-AP in the progression group were all higher than those in the stable group, while the liver/spleen CT values were lower than the stable group (all P< 0.05). Liver/spleen CT values were protective factors (HR=0.245, 95% CI: 0.098– 0.613) for the tendency towards severe HTG-AP, while BISAP scores (HR=4.536) and serum sPD-L1 (HR=4.345) were risk factors (all P< 0.05). The combined prediction of the three indicators for the severity of HTG-AP had an AUC of 0.826, with a sensitivity of 0.89 and a specificity of 0.79, and the efficacy was superior to that of a single indicator (all P< 0.05).
Conclusion: Liver/spleen CT values, BISAP scores and serum sPD-L1 have certain predictive value for the tendency of severe deterioration in patients with HTG-AP within 24 hours of onset. When these three factors are combined, the predictive efficacy is even better.
Keywords: acute pancreatitis, hyperlipidemia, fatty liver, BISAP score, soluble programmed death ligand 1, severity
1Department of Spleen, Stomach and Hepatology, Guangxi International Zhuang Medical Hospital, Nanning, Guangxi, People’s Republic of China; 2Department of Gastroenterology, Wuzhou Gongren Hospital, Wuzhou, Guangxi, People’s Republic of China; 3Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoping Lv, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi, 530021, People’s Republic of China, Email prvv42@sina.com
Objective: To explore the predictive value of liver/spleen CT Value, bedside index for severity in acute pancreatitis (BISAP) score combined with serum soluble programmed death ligand 1 (sPD-L1) within 24 hours of onset for the severity tendency of hyperlipidemic acute pancreatitis (HTG-AP).
Methods: A retrospective study was conducted on the clinical data of 102 patients with mild to moderate HTG-AP. These patients were divided into the progression group (24 cases) and the stable group (78 cases) based on whether they progressed to severe HTG-AP. The liver/spleen CT values, BISAP scores, serum sPD-L1 levels and blood urea nitrogen (BUN) levels were compared within 24 hours of onset in the two groups. The COX regression model was used to analyze the influencing factors of the tendency of HTG-AP severity. The predictive efficacy of each indicator was evaluated through the Receiver operating characteristic curves (ROC).
Results: The BUN, BISAP score, serum sPD-L1 levels, and the proportion of moderate HTG-AP in the progression group were all higher than those in the stable group, while the liver/spleen CT values were lower than the stable group (all P< 0.05). Liver/spleen CT values were protective factors (HR=0.245, 95% CI: 0.098– 0.613) for the tendency towards severe HTG-AP, while BISAP scores (HR=4.536) and serum sPD-L1 (HR=4.345) were risk factors (all P< 0.05). The combined prediction of the three indicators for the severity of HTG-AP had an AUC of 0.826, with a sensitivity of 0.89 and a specificity of 0.79, and the efficacy was superior to that of a single indicator (all P< 0.05).
Conclusion: Liver/spleen CT values, BISAP scores and serum sPD-L1 have certain predictive value for the tendency of severe deterioration in patients with HTG-AP within 24 hours of onset. When these three factors are combined, the predictive efficacy is even better.
Keywords: acute pancreatitis, hyperlipidemia, fatty liver, BISAP score, soluble programmed death ligand 1, severity