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已发表论文
外泌体在皮肤病治疗剂、载体及生物标志物方面的潜在应用
Authors Li W, Li H, Fan L, Zhao R, Dong F, Jia X, Yin L, Yang S, Zhao D , Wang J
Received 3 July 2025
Accepted for publication 28 September 2025
Published 15 October 2025 Volume 2025:20 Pages 12627—12658
DOI https://doi.org/10.2147/IJN.S547871
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Krishna Nune
Wenjing Li,1 Haiyan Li,2 Liangliang Fan,1 Ronghua Zhao,1 Fusong Dong,1 Xuxia Jia,1 Lijia Yin,1 Song Yang,1 Daqing Zhao,1 Jiawen Wang1
1Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 2Experimental Centre, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China
Correspondence: Jiawen Wang, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Boshuo Road, Nanguan District, Changchun, Jilin, 130117, People’s Republic of China, Email wangjiawen1229@163.com
Abstract: Exosomes, owing to their potent capabilities for intercellular communication, have great potential in modern medicine. The pathogenesis of skin diseases is predominantly characterized by immune imbalance and impaired regenerative processes. Exosomes are rich in microRNAs, lipids, and proteins, which play a crucial role in immune regulation and regenerative medicine. Recent studies have highlighted the involvement of exosomes in the therapeutic management of dermatological disorders. This review provides a comprehensive overview of the potential therapeutic applications of exosomes in autoimmune skin conditions, such as systemic lupus erythematosus, systemic sclerosis, psoriasis, and vitiligo, as well as their roles in skin wound healing, skin aging, scar formation, skin flap regeneration, hair regeneration, and other skin regenerative disorders. The paper examines various exosome delivery methods and evaluates current clinical trials, identifying challenges related to exosome isolation, preservation, active components, mechanistic understanding, and clinical translation. Furthermore, it delineates future research directions and proposes innovative strategies for advancing exosome-based therapies in dermatology.
Keywords: Exosomes, Autoimmune skin diseases, Skin regeneration, Engineered exosomes
1Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China; 2Experimental Centre, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China
Correspondence: Jiawen Wang, Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Boshuo Road, Nanguan District, Changchun, Jilin, 130117, People’s Republic of China, Email wangjiawen1229@163.com
Abstract: Exosomes, owing to their potent capabilities for intercellular communication, have great potential in modern medicine. The pathogenesis of skin diseases is predominantly characterized by immune imbalance and impaired regenerative processes. Exosomes are rich in microRNAs, lipids, and proteins, which play a crucial role in immune regulation and regenerative medicine. Recent studies have highlighted the involvement of exosomes in the therapeutic management of dermatological disorders. This review provides a comprehensive overview of the potential therapeutic applications of exosomes in autoimmune skin conditions, such as systemic lupus erythematosus, systemic sclerosis, psoriasis, and vitiligo, as well as their roles in skin wound healing, skin aging, scar formation, skin flap regeneration, hair regeneration, and other skin regenerative disorders. The paper examines various exosome delivery methods and evaluates current clinical trials, identifying challenges related to exosome isolation, preservation, active components, mechanistic understanding, and clinical translation. Furthermore, it delineates future research directions and proposes innovative strategies for advancing exosome-based therapies in dermatology.
Keywords: Exosomes, Autoimmune skin diseases, Skin regeneration, Engineered exosomes