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已发表论文
SAPHO 综合征误诊为脊柱感染：病例系列
Authors Yang X , Gu J, Zeng C, Pan D , Cao H, Qian Q, Chen L
Received 7 March 2025
Accepted for publication 9 October 2025
Published 16 October 2025 Volume 2025:18 Pages 1329—1341
DOI https://doi.org/10.2147/IMCRJ.S526910
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Yu-Ping Ning
Xiaoyan Yang, Jina Gu, Chengjun Zeng, Danmei Pan, Hongchao Cao, Qinbin Qian, Lin Chen
Infectious Diseases Department, Ningbo No. 2 Hospital, Ningbo, Zhejiang, 315010, People’s Republic of China
Correspondence: Lin Chen, Infectious Diseases Department, Ningbo No. 2 Hospital, Ningbo, Zhejiang, CN 315010, Tel +8613566636155, Fax +86057487085742, Email chenlin2111@163.com
Abstract: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory disorder characterized by osteoarticular symptoms and dermatological lesions. This case series aims to enhance clinical recognition and reduce misdiagnosis by presenting three patients initially misdiagnosed with spinal infection at external hospitals. All cases presented with worsening back pain and recurrent palmoplantar pustulosis (PPP), one of whom also had comorbid psoriasis. Imaging revealed multifocal purely osteolytic lesions in one patient and mixed osteolytic-osteosclerotic changes in the other two. After exclusion of infectious and neoplastic etiologies, all patients were diagnosed with SAPHO syndrome and showed significant improvement with symptomatic treatment. In conclusion, this case series demonstrated that SAPHO syndrome should be considered in patients with back pain and PPP after excluding infection and tumor.
Keywords: SAPHO syndrome, PPP, acne, bullhead sign, spinal infection
Infectious Diseases Department, Ningbo No. 2 Hospital, Ningbo, Zhejiang, 315010, People’s Republic of China
Correspondence: Lin Chen, Infectious Diseases Department, Ningbo No. 2 Hospital, Ningbo, Zhejiang, CN 315010, Tel +8613566636155, Fax +86057487085742, Email chenlin2111@163.com
Abstract: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory disorder characterized by osteoarticular symptoms and dermatological lesions. This case series aims to enhance clinical recognition and reduce misdiagnosis by presenting three patients initially misdiagnosed with spinal infection at external hospitals. All cases presented with worsening back pain and recurrent palmoplantar pustulosis (PPP), one of whom also had comorbid psoriasis. Imaging revealed multifocal purely osteolytic lesions in one patient and mixed osteolytic-osteosclerotic changes in the other two. After exclusion of infectious and neoplastic etiologies, all patients were diagnosed with SAPHO syndrome and showed significant improvement with symptomatic treatment. In conclusion, this case series demonstrated that SAPHO syndrome should be considered in patients with back pain and PPP after excluding infection and tumor.
Keywords: SAPHO syndrome, PPP, acne, bullhead sign, spinal infection