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已发表论文
乳头状甲状腺癌和甲状腺结节中多类群微生物谱分析：口腔、肠道和组织微生物群的关联
Authors Chang W, Kang L, Lan T, Zhou C, Pang B , Jiang X, Zhao Z
Received 22 July 2025
Accepted for publication 10 October 2025
Published 17 October 2025 Volume 2025:18 Pages 14391—14404
DOI https://doi.org/10.2147/JIR.S552936
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Junhao Wang
Wang Chang,1,2,* Longfei Kang,1,3,* Tianhao Lan,1 Chuanmin Zhou,1,3 Bo Pang,1,3 Xia Jiang,1,3 Zengren Zhao1,3
1Department of Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Head and Neck Surgery, Tangshan Gongren Hospital, Tangshan, Hebei, People’s Republic of China; 3Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, The First Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zengren Zhao, Department of Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email zhaozengren@hebmu.edu.cn Bo Pang, Department of Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email 59203915@hebmu.edu.cn
Purpose: Microbial communities have emerged as crucial regulators in the initiation and progression of thyroid cancer. However, most studies focus on single microbial sources, and the interplay between microbes across different ecological niches and their impact on thyroid carcinogenesis are largely unknown.
Patients and Methods: In this study, we collected tissue, oral, and fecal samples from 32 patients with benign thyroid nodules (BTN) and 32 patients with papillary thyroid carcinoma (PTC). The oral and fecal samples were subjected to 16S rRNA sequencing, while the tissue samples were analyzed using 5R 16S sequencing to comprehensively characterize the microbial communities.
Results: Clustering analysis using the Dirichlet Multinomial Mixture model with Laplace approximation identified two distinct oral microbial community types (O_1 and O_2) and three fecal types (F_1, F_2, and F_3). Microbial diversity patterns in thyroid tissues mirrored those observed in oral and fecal samples, suggesting potential microbial translocation or systemic interactions. Inflammatory markers were significantly elevated in PTC patients relative to BTN controls. Notably, the genus Veillonella, a potential anti-tumor biomarker, was significantly reduced in PTC samples across niches.
Conclusion: This study highlights the pivotal role of oral and intestinal microbiota in PTC development, emphasizing the interplay between microbial composition, inflammatory processes, and immune regulation in tumor progression. The discovery of Veillonella as a potential anti-tumor microbe, along with evidence of microbial translocation, opens new possibilities for targeted therapeutic strategies.
Keywords: papillary thyroid carcinoma, multi-niche microbiota, 16S rRNA sequencing, inflammatory factors, Veillonella
1Department of Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Head and Neck Surgery, Tangshan Gongren Hospital, Tangshan, Hebei, People’s Republic of China; 3Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, The First Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zengren Zhao, Department of Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email zhaozengren@hebmu.edu.cn Bo Pang, Department of Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email 59203915@hebmu.edu.cn
Purpose: Microbial communities have emerged as crucial regulators in the initiation and progression of thyroid cancer. However, most studies focus on single microbial sources, and the interplay between microbes across different ecological niches and their impact on thyroid carcinogenesis are largely unknown.
Patients and Methods: In this study, we collected tissue, oral, and fecal samples from 32 patients with benign thyroid nodules (BTN) and 32 patients with papillary thyroid carcinoma (PTC). The oral and fecal samples were subjected to 16S rRNA sequencing, while the tissue samples were analyzed using 5R 16S sequencing to comprehensively characterize the microbial communities.
Results: Clustering analysis using the Dirichlet Multinomial Mixture model with Laplace approximation identified two distinct oral microbial community types (O_1 and O_2) and three fecal types (F_1, F_2, and F_3). Microbial diversity patterns in thyroid tissues mirrored those observed in oral and fecal samples, suggesting potential microbial translocation or systemic interactions. Inflammatory markers were significantly elevated in PTC patients relative to BTN controls. Notably, the genus Veillonella, a potential anti-tumor biomarker, was significantly reduced in PTC samples across niches.
Conclusion: This study highlights the pivotal role of oral and intestinal microbiota in PTC development, emphasizing the interplay between microbial composition, inflammatory processes, and immune regulation in tumor progression. The discovery of Veillonella as a potential anti-tumor microbe, along with evidence of microbial translocation, opens new possibilities for targeted therapeutic strategies.
Keywords: papillary thyroid carcinoma, multi-niche microbiota, 16S rRNA sequencing, inflammatory factors, Veillonella