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已发表论文
免疫功能正常的青少年马尔尼菲篮状菌皮肤感染：一例报告
Authors Chen Y , Li X, Bi C, Yang Y, Xiong S, Tian X , Zhong D, Gan Y , Gao A
Received 5 June 2025
Accepted for publication 17 September 2025
Published 21 October 2025 Volume 2025:18 Pages 2701—2706
DOI https://doi.org/10.2147/CCID.S544483
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Rungsima Wanitphakdeedecha
Yue Chen,* Xiaodong Li,* Chao Bi, Yan Yang, Siying Xiong, Xin Tian, Daoqing Zhong, Yichuan Gan, Aili Gao
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Aili Gao, Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, People’s Republic of China, Email alicegao197897@163.com
Abstract: Talaromyces marneffei (TM) infection is a rare but potentially fatal deep fungal disease that typically affects immunocompromised individuals in endemic regions. However, an increasing number of cases have been reported in HIV-negative, immunocompetent patients without classical risk factors. We report the case of a 15-year-old girl residing in urban southern China who presented with chronic cutaneous plaques and cervical lymphadenopathy, initially misdiagnosed as tuberculous lymphadenitis. Despite one year of anti-tuberculosis therapy, her condition worsened and liver dysfunction developed. Subsequent skin biopsy, fungal culture, and metagenomic next-generation sequencing (mNGS) confirmed localized cutaneous TM infection. The patient responded well to oral itraconazole, and lesions resolved after four months of treatment, with no recurrence during an 18-month follow-up. This case highlights the importance of considering deep fungal infections in the differential diagnosis of chronic granulomatous skin lesions, even in immunocompetent hosts, and emphasizes the diagnostic utility of mNGS in atypical presentations.
Keywords: Talaromyces marneffei, cutaneous fungal infection, adolescent, HIV-negative, itraconazole, granulomatous dermatitis, metagenomic next-generation sequencing, mNGS, deep mycosis
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Aili Gao, Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, People’s Republic of China, Email alicegao197897@163.com
Abstract: Talaromyces marneffei (TM) infection is a rare but potentially fatal deep fungal disease that typically affects immunocompromised individuals in endemic regions. However, an increasing number of cases have been reported in HIV-negative, immunocompetent patients without classical risk factors. We report the case of a 15-year-old girl residing in urban southern China who presented with chronic cutaneous plaques and cervical lymphadenopathy, initially misdiagnosed as tuberculous lymphadenitis. Despite one year of anti-tuberculosis therapy, her condition worsened and liver dysfunction developed. Subsequent skin biopsy, fungal culture, and metagenomic next-generation sequencing (mNGS) confirmed localized cutaneous TM infection. The patient responded well to oral itraconazole, and lesions resolved after four months of treatment, with no recurrence during an 18-month follow-up. This case highlights the importance of considering deep fungal infections in the differential diagnosis of chronic granulomatous skin lesions, even in immunocompetent hosts, and emphasizes the diagnostic utility of mNGS in atypical presentations.
Keywords: Talaromyces marneffei, cutaneous fungal infection, adolescent, HIV-negative, itraconazole, granulomatous dermatitis, metagenomic next-generation sequencing, mNGS, deep mycosis