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已发表论文
色素性扁平苔藓中浆细胞占优势：年轻女性罕见病例
Received 21 July 2025
Accepted for publication 4 October 2025
Published 21 October 2025 Volume 2025:18 Pages 2713—2717
DOI https://doi.org/10.2147/CCID.S555168
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Yuxi Zhou,1 Yingqiu Bao,2 Yu Fu2
1Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2Department of Dermatology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
Correspondence: Yu Fu, Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dong da Hua Road, Dongcheng District, Beijing, 100730, People’s Republic of China, Email 13601326358@163.com
Abstract: Lichen planus pigmentosus (LPP), a rare variant of lichen planus, characterized by the insidious onset of dark brown to gray macules. In this report, we present a unique case of LPP in a 30-year-old female patient who developed diffuse hyperpigmented macules with nail dystrophy. Notably, histopathology revealed classic lichenoid interface dermatitis with predominant plasma cell infiltration in the papillary dermis, confirmed by strong CD38 and CD138 immunoreactivity. Laboratory evaluation revealed elevated serum Kappa light chain and thyroid stimulating hormone levels, raising the possibility of immune dysregulation. No evidence of plasma cell malignancy was found after further hematologic evaluation. To our knowledge, this may be the first reported case of plasma cell-rich LPP in a young female with concurrent nail involvement and isolated serum kappa light chain elevation without evidence of clonality. Awareness of this entity is essential for differentiating it from mimickers such as cutaneous plasmacytosis, multicentric Castleman disease, and secondary syphilis. This case highlights the need for heightened awareness of this variant and its possible systemic associations, and underscores the importance of integrating histopathology, immunophenotyping, and laboratory workup to avoid misdiagnosis and guide clinical care.
Keywords: lichen planus pigmentosus, pigmentary disorders, plasma cell, histopathology, immune dysregulation
1Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2Department of Dermatology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
Correspondence: Yu Fu, Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dong da Hua Road, Dongcheng District, Beijing, 100730, People’s Republic of China, Email 13601326358@163.com
Abstract: Lichen planus pigmentosus (LPP), a rare variant of lichen planus, characterized by the insidious onset of dark brown to gray macules. In this report, we present a unique case of LPP in a 30-year-old female patient who developed diffuse hyperpigmented macules with nail dystrophy. Notably, histopathology revealed classic lichenoid interface dermatitis with predominant plasma cell infiltration in the papillary dermis, confirmed by strong CD38 and CD138 immunoreactivity. Laboratory evaluation revealed elevated serum Kappa light chain and thyroid stimulating hormone levels, raising the possibility of immune dysregulation. No evidence of plasma cell malignancy was found after further hematologic evaluation. To our knowledge, this may be the first reported case of plasma cell-rich LPP in a young female with concurrent nail involvement and isolated serum kappa light chain elevation without evidence of clonality. Awareness of this entity is essential for differentiating it from mimickers such as cutaneous plasmacytosis, multicentric Castleman disease, and secondary syphilis. This case highlights the need for heightened awareness of this variant and its possible systemic associations, and underscores the importance of integrating histopathology, immunophenotyping, and laboratory workup to avoid misdiagnosis and guide clinical care.
Keywords: lichen planus pigmentosus, pigmentary disorders, plasma cell, histopathology, immune dysregulation