109568
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
应用眼前节光学相干断层扫描评估糖尿病视网膜病变不同阶段的角膜上皮厚度
Authors Lin Y , Zhao Z, Ma D, Ma Y, Chen S, Cai C, Xiong Y
Received 31 May 2025
Accepted for publication 13 October 2025
Published 21 October 2025 Volume 2025:19 Pages 3889—3898
DOI https://doi.org/10.2147/OPTH.S544040
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Yongdong Lin, Zifeng Zhao, Di Ma, Yueting Ma, Shirong Chen, Chang Cai, Yongqun Xiong
Department of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People’s Republic of China
Correspondence: Yongqun Xiong, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Dong xia Road, Shantou, Guangdong, People’s Republic of China, Email xyq@jsiec.org
Purpose: To compare the corneal epithelial thickness (CET), the density and number of central corneal subbasal nerve plexus (CSNP) between controls and different types of diabetic retinopathy in type 2 diabetics.
Methods: This cross-sectional study included participants who underwent a comprehensive evaluation comprising anterior segment optical coherence tomography, Keratograph 5M, fluorescein tear break-up time, and in vivo confocal corneal microscopy. Based on the Early Treatment Diabetic Retinopathy Study classification, patients with diabetes were categorized into no diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group.
Results: A total of 75 eyes were examined— 20 eyes from 20 control subjects and 55 eyes from 55 patients with diabetes (20 NDR, 14 NPDR, 21 PDR). Compared to controls, diabetic eyes exhibited significant increases in corneal thickness (CT) in each region (all P < 0.05), as well as a decrease in CSNP density (15.18 ± 2.60 vs 11.77 ± 3.77, P = 0.040) and number (39.27 ± 6.87 vs 28.67 ± 9.71, P < 0.001). In the PDR group, CET in all areas (except at 6 mm) was significantly thinner (all P < 0.05). Univariate analysis indicated that central CET and CET measured 2 mm from the center were associated with age, CSNP density, and superior meibomian gland dropout. Multivariate analysis identified CSNP density as the only significant factor associated with CET (P < 0.05).
Conclusion: Diabetic eyes exhibit a reduction in CSNP density and number and an increase in CT. CET is significantly thinner in patients with PDR. Furthermore, CET correlates with CSNP density.
Keywords: central corneal subbasal nerve, corneal epithelial thickness, ocular surface parameter, diabetes mellitus, corneal thickness
Department of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People’s Republic of China
Correspondence: Yongqun Xiong, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Dong xia Road, Shantou, Guangdong, People’s Republic of China, Email xyq@jsiec.org
Purpose: To compare the corneal epithelial thickness (CET), the density and number of central corneal subbasal nerve plexus (CSNP) between controls and different types of diabetic retinopathy in type 2 diabetics.
Methods: This cross-sectional study included participants who underwent a comprehensive evaluation comprising anterior segment optical coherence tomography, Keratograph 5M, fluorescein tear break-up time, and in vivo confocal corneal microscopy. Based on the Early Treatment Diabetic Retinopathy Study classification, patients with diabetes were categorized into no diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group.
Results: A total of 75 eyes were examined— 20 eyes from 20 control subjects and 55 eyes from 55 patients with diabetes (20 NDR, 14 NPDR, 21 PDR). Compared to controls, diabetic eyes exhibited significant increases in corneal thickness (CT) in each region (all P < 0.05), as well as a decrease in CSNP density (15.18 ± 2.60 vs 11.77 ± 3.77, P = 0.040) and number (39.27 ± 6.87 vs 28.67 ± 9.71, P < 0.001). In the PDR group, CET in all areas (except at 6 mm) was significantly thinner (all P < 0.05). Univariate analysis indicated that central CET and CET measured 2 mm from the center were associated with age, CSNP density, and superior meibomian gland dropout. Multivariate analysis identified CSNP density as the only significant factor associated with CET (P < 0.05).
Conclusion: Diabetic eyes exhibit a reduction in CSNP density and number and an increase in CT. CET is significantly thinner in patients with PDR. Furthermore, CET correlates with CSNP density.
Keywords: central corneal subbasal nerve, corneal epithelial thickness, ocular surface parameter, diabetes mellitus, corneal thickness