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已发表论文
利用 IVIM-DWI 和 IDEAL-IQ 序列评估骨质疏松症患者的腰椎微结构
Authors Shi Z, Hu L, Su D, Yang Z, Liu W, Yuan K, Wang T, Cui Z, Qin J, Zhang Y
Received 17 May 2025
Accepted for publication 14 September 2025
Published 20 September 2025 Volume 2025:20 Pages 1635—1646
DOI https://doi.org/10.2147/CIA.S541103
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Nandu Goswami
Zhaojuan Shi,1 Lingdong Hu,2 Datian Su,1 Zhe Yang,1 Weiwei Liu,1 Kemei Yuan,1 Tiantian Wang,1 Zhaoping Cui,1 Jian Qin,1 Yue Zhang1
1Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, Shandong, 271000, People’s Republic of China; 2Department of Medicine, Tai’an Disabled Soldiers’ Hospital of Shandong Province, Tai’an, Shandong, 271000, People’s Republic of China
Correspondence: Jian Qin, Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai’an City, Shandong Province, 271000, People’s Republic of China, Tel +86 0538-6238002, Email sdqinjian@126.com Yue Zhang, Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai’an City, Shandong Province, 271000, People’s Republic of China, Tel +86 0538-6238002, Email 303570746@qq.com
Background: Currently, dual-energy X-ray absorptiometry (DEXA) and quantitative CT (QCT) are commonly used in clinical practice to measure bone mineral density (BMD), offering diagnostic value but involving radiation and inability to visualize bone microstructure. This study aims to assess lumbar spine bone microstructure changes in normal, osteopenic, and osteoporotic groups using IVIM-DWI and IDEAL-IQ sequences to provide useful information for clinical practice.
Methods: A total of 346 patients (50– 87 years, 232 females, 114 males) underwent spinal DEXA and MRI. Based on the BMD obtained from DEXA, the patients were stratified into: normal (n=79), osteopenia (n=92), and OP (n=175) groups. Then to evaluated the results of IVIM-DWI and IDEAL-IQ and extracted quantitative parameters from regions of interest covering the L1 to L4 vertebrae. Group comparisons used One-way analysis of variance and the Kruskal‒Wallis H-test. Receiver operating characteristic (ROC) and Spearman’s analyses evaluated diagnostic performance and correlations.
Results: Significant differences existed in the ADCslow, f, FF and R2* between groups (P< 0.05). BMD was weakly positively correlated with ADCslow, f, and R2* (r=0.494, 0.153, 0.182, 0.029, P< 0.001) but a negative correlation with FF (r=− 0.402, P< 0.001). BMD and the ADCslow and R2* decreased but FF increased with age (P< 0.05 for all), whereas no significant association existed between age and ADCfast or f value (P> 0.05). FF had the highest areas under the curve (AUCs) (0.624, 0.831 and 0.747) and sensitivity (72.2%, 70.9% and 81.5%) in differentiating normal from osteopenia patients, normal from osteoporosis patients, and osteopenia from osteoporosis patients, respectively. ADCslow and f had the highest specificity (88%) in differentiating between normal and osteopenia patients, while ADCslow had the highest specificity (91.4%) in differentiating between normal and osteoporosis patients.
Conclusion: Quantitative parameters extracted from IVIM-DWI and IDEAL-IQ have the potential to become good biomarkers for diagnosing OP.
Keywords: IVIM-DWI, IDEAL-IQ, Quantitative evaluation, Osteoporosis
1Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, Shandong, 271000, People’s Republic of China; 2Department of Medicine, Tai’an Disabled Soldiers’ Hospital of Shandong Province, Tai’an, Shandong, 271000, People’s Republic of China
Correspondence: Jian Qin, Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai’an City, Shandong Province, 271000, People’s Republic of China, Tel +86 0538-6238002, Email sdqinjian@126.com Yue Zhang, Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, No. 366 Taishan Street, Tai’an City, Shandong Province, 271000, People’s Republic of China, Tel +86 0538-6238002, Email 303570746@qq.com
Background: Currently, dual-energy X-ray absorptiometry (DEXA) and quantitative CT (QCT) are commonly used in clinical practice to measure bone mineral density (BMD), offering diagnostic value but involving radiation and inability to visualize bone microstructure. This study aims to assess lumbar spine bone microstructure changes in normal, osteopenic, and osteoporotic groups using IVIM-DWI and IDEAL-IQ sequences to provide useful information for clinical practice.
Methods: A total of 346 patients (50– 87 years, 232 females, 114 males) underwent spinal DEXA and MRI. Based on the BMD obtained from DEXA, the patients were stratified into: normal (n=79), osteopenia (n=92), and OP (n=175) groups. Then to evaluated the results of IVIM-DWI and IDEAL-IQ and extracted quantitative parameters from regions of interest covering the L1 to L4 vertebrae. Group comparisons used One-way analysis of variance and the Kruskal‒Wallis H-test. Receiver operating characteristic (ROC) and Spearman’s analyses evaluated diagnostic performance and correlations.
Results: Significant differences existed in the ADCslow, f, FF and R2* between groups (P< 0.05). BMD was weakly positively correlated with ADCslow, f, and R2* (r=0.494, 0.153, 0.182, 0.029, P< 0.001) but a negative correlation with FF (r=− 0.402, P< 0.001). BMD and the ADCslow and R2* decreased but FF increased with age (P< 0.05 for all), whereas no significant association existed between age and ADCfast or f value (P> 0.05). FF had the highest areas under the curve (AUCs) (0.624, 0.831 and 0.747) and sensitivity (72.2%, 70.9% and 81.5%) in differentiating normal from osteopenia patients, normal from osteoporosis patients, and osteopenia from osteoporosis patients, respectively. ADCslow and f had the highest specificity (88%) in differentiating between normal and osteopenia patients, while ADCslow had the highest specificity (91.4%) in differentiating between normal and osteoporosis patients.
Conclusion: Quantitative parameters extracted from IVIM-DWI and IDEAL-IQ have the potential to become good biomarkers for diagnosing OP.
Keywords: IVIM-DWI, IDEAL-IQ, Quantitative evaluation, Osteoporosis