108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
老年患者非体外循环冠状动脉旁路移植术前心理症状与术后慢性疼痛的相关性：急性疼痛的中介分析
Authors Cui S, Wang S, Di L, Yan L, Huang P, Wang X, Fu Z, Huang L
Received 27 April 2025
Accepted for publication 11 September 2025
Published 22 September 2025 Volume 2025:18 Pages 4901—4913
DOI https://doi.org/10.2147/JPR.S537096
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kushang V Patel
Sichen Cui,1 Shizhao Wang,1 Lichao Di,1 Luguang Yan,1 Peiying Huang,1 Xueji Wang,1 Zheng Fu,1 Lining Huang1,2
1Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2The Key Laboratory of Clinical Neurology, Ministry of Education, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China
Correspondence: Lining Huang; Zheng Fu, Department of Anesthesiology, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, People’s Republic of China, Tel +86 15803213730 ; +86 15100198787, Email 27701226@hebmu.edu.cn; fuzh2029@163.com
Purpose: This study aimed to investigate the association between preoperative psychological symptoms and chronic postsurgical pain (CPSP) in older patients undergoing off-pump coronary artery bypass grafting, and explore the mediating effect of acute postsurgical pain.
Patients and Methods: A total of 172 patients aged ≥ 60 years, undergoing off-pump CABG were enrolled. Preoperative anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Acute pain intensity was recorded daily (postoperative days 1– 5), with time-weighted average (TWA) scores calculated. CPSP was defined as persistent pain at 3 months after surgery. Logistic regression evaluated associations between preoperative psychological symptoms (individually and by stratification) and CPSP. Mediation analysis explored the role of acute pain between preoperative psychological factors and CPSP.
Results: Prevalence of CPSP was 37.8% (29.1% mild, 8.7% moderate-to-severe). CPSP patients exhibited higher female proportion (36.9%, P=0.012), precordial pain (56.9%, P=0.044), anxiety (46.2%, P< 0.001), depression (35.4%, P< 0.001), and TWA scores (4.0 vs 3.0, P< 0.001). Preoperative anxiety (OR = 3.64, P = 0.002) and depression (OR = 3.26, P = 0.004) independently predicted CPSP, with comorbid symptoms conferring higher risk (OR = 7.83, P = 0.002). Acute pain partially mediated anxiety-CPSP association (indirect effect: 7.7%; P = 0.002).
Conclusion: Preoperative anxiety and depression elevate CPSP risk in older off-pump CABG patients. Acute postsurgical pain partially mediates the anxiety-CPSP relationship. Integrated perioperative strategies targeting psychological health and pain management are critical to mitigate long-term pain outcomes.
Keywords: chronic postsurgical pain, preoperative psychological symptoms, mediation analysis, acute pain, aging
1Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2The Key Laboratory of Clinical Neurology, Ministry of Education, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China
Correspondence: Lining Huang; Zheng Fu, Department of Anesthesiology, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050000, People’s Republic of China, Tel +86 15803213730 ; +86 15100198787, Email 27701226@hebmu.edu.cn; fuzh2029@163.com
Purpose: This study aimed to investigate the association between preoperative psychological symptoms and chronic postsurgical pain (CPSP) in older patients undergoing off-pump coronary artery bypass grafting, and explore the mediating effect of acute postsurgical pain.
Patients and Methods: A total of 172 patients aged ≥ 60 years, undergoing off-pump CABG were enrolled. Preoperative anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Acute pain intensity was recorded daily (postoperative days 1– 5), with time-weighted average (TWA) scores calculated. CPSP was defined as persistent pain at 3 months after surgery. Logistic regression evaluated associations between preoperative psychological symptoms (individually and by stratification) and CPSP. Mediation analysis explored the role of acute pain between preoperative psychological factors and CPSP.
Results: Prevalence of CPSP was 37.8% (29.1% mild, 8.7% moderate-to-severe). CPSP patients exhibited higher female proportion (36.9%, P=0.012), precordial pain (56.9%, P=0.044), anxiety (46.2%, P< 0.001), depression (35.4%, P< 0.001), and TWA scores (4.0 vs 3.0, P< 0.001). Preoperative anxiety (OR = 3.64, P = 0.002) and depression (OR = 3.26, P = 0.004) independently predicted CPSP, with comorbid symptoms conferring higher risk (OR = 7.83, P = 0.002). Acute pain partially mediated anxiety-CPSP association (indirect effect: 7.7%; P = 0.002).
Conclusion: Preoperative anxiety and depression elevate CPSP risk in older off-pump CABG patients. Acute postsurgical pain partially mediates the anxiety-CPSP relationship. Integrated perioperative strategies targeting psychological health and pain management are critical to mitigate long-term pain outcomes.
Keywords: chronic postsurgical pain, preoperative psychological symptoms, mediation analysis, acute pain, aging