108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
黄斑中心厚度和黄斑无血管区是早期糖尿病视网膜病变的指标
Received 27 June 2025
Accepted for publication 9 September 2025
Published 22 September 2025 Volume 2025:19 Pages 3505—3514
DOI https://doi.org/10.2147/OPTH.S544037
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Yousef Fouad
Qingquan Wei,1 Wenying Wang,2 Qinghua Qiu1,3,4
1Department of Ophthalmology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Ophthalmology Center, Beijing, People’s Republic of China; 3High Altitude Ocular Disease Research Center of People’s Hospital of Shigatse City and Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shigatse, People’s Republic of China; 4Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, Xizang, People’s Republic of China
Correspondence: Qinghua Qiu, Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai, People’s Republic of China, Tel +86 13386259756, Email qinghuaqiu@163.com Wenying Wang, Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Ophthalmology Center, Beijing, People’s Republic of China, Email wwy191@163.com
Purpose: Diabetic retinopathy (DR) is one of the most common complications in diabetic patients, and early diagnosis and intervention are crucial for slowing disease progression. This study aims to investigate the changes in central macular thickness (CMT) and foveal avascular zone (FAZ) area in healthy individuals, patients with no apparent diabetic retinopathy (NDR), and patients with non-proliferative diabetic retinopathy (NPDR), and to explore the potential risk factors for early DR.
Methods: This cross-sectional study included 60 healthy individuals, 60 patients with no DR, and 60 patients with mild NPDR. All participants underwent comprehensive ophthalmic examinations. Central macular thickness (CMT) was measured using optical coherence tomography (OCT), and the FAZ area was measured using optical coherence tomography angiography (OCTA). The potential associations between CMT and FAZ area and systemic risk factors for early DR (including duration of diabetes, body mass index (BMI), glycated hemoglobin (HbA1c), lipid profile, and blood pressure) were analyzed.
Results: Significant differences in CMT and FAZ area were observed in both the right and left eyes of the NPDR and NDR groups compared to the control group (p< 0.05). The CMT and FAZ area also showed significant differences between the NPDR and NDR groups (p< 0.05). Additionally, CMT was positively correlated with the duration of diabetes, BMI, total cholesterol (TC), triglyceride (TG), systolic blood pressure, and diastolic blood pressure (p< 0.05). FAZ area was positively correlated with the duration of diabetes and BMI (p< 0.05).
Conclusion: The increase in CMT and the reduction in macular perfusion may be the earliest retinal structural changes in diabetic patients, and both changes are closely related to systemic factors. These findings provide important structural and metabolic indicators for the early identification and intervention of diabetic retinopathy.
Keywords: diabetic retinopathy, central macular thickness, foveal avascular zone, optical coherence tomography angiography
1Department of Ophthalmology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Ophthalmology Center, Beijing, People’s Republic of China; 3High Altitude Ocular Disease Research Center of People’s Hospital of Shigatse City and Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shigatse, People’s Republic of China; 4Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, Xizang, People’s Republic of China
Correspondence: Qinghua Qiu, Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai, People’s Republic of China, Tel +86 13386259756, Email qinghuaqiu@163.com Wenying Wang, Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Ophthalmology Center, Beijing, People’s Republic of China, Email wwy191@163.com
Purpose: Diabetic retinopathy (DR) is one of the most common complications in diabetic patients, and early diagnosis and intervention are crucial for slowing disease progression. This study aims to investigate the changes in central macular thickness (CMT) and foveal avascular zone (FAZ) area in healthy individuals, patients with no apparent diabetic retinopathy (NDR), and patients with non-proliferative diabetic retinopathy (NPDR), and to explore the potential risk factors for early DR.
Methods: This cross-sectional study included 60 healthy individuals, 60 patients with no DR, and 60 patients with mild NPDR. All participants underwent comprehensive ophthalmic examinations. Central macular thickness (CMT) was measured using optical coherence tomography (OCT), and the FAZ area was measured using optical coherence tomography angiography (OCTA). The potential associations between CMT and FAZ area and systemic risk factors for early DR (including duration of diabetes, body mass index (BMI), glycated hemoglobin (HbA1c), lipid profile, and blood pressure) were analyzed.
Results: Significant differences in CMT and FAZ area were observed in both the right and left eyes of the NPDR and NDR groups compared to the control group (p< 0.05). The CMT and FAZ area also showed significant differences between the NPDR and NDR groups (p< 0.05). Additionally, CMT was positively correlated with the duration of diabetes, BMI, total cholesterol (TC), triglyceride (TG), systolic blood pressure, and diastolic blood pressure (p< 0.05). FAZ area was positively correlated with the duration of diabetes and BMI (p< 0.05).
Conclusion: The increase in CMT and the reduction in macular perfusion may be the earliest retinal structural changes in diabetic patients, and both changes are closely related to systemic factors. These findings provide important structural and metabolic indicators for the early identification and intervention of diabetic retinopathy.
Keywords: diabetic retinopathy, central macular thickness, foveal avascular zone, optical coherence tomography angiography