108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
血小板在脓毒症中作为免疫介质的关键作用
Authors Yang X, Song J, Ma H, Hua N, Bai Y, Ju Y, Shen JW, Zheng W, Jiang S
Received 15 May 2025
Accepted for publication 9 August 2025
Published 16 September 2025 Volume 2025:18 Pages 12825—12845
DOI https://doi.org/10.2147/JIR.S535701
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Anh Ngo
Xiaohui Yang,1,2 Jiasheng Song,1,2 Hui Ma,2 Ning Hua,2 Yanan Bai,2,3 Yuanzhi Ju,2,3 Jia-Wei Shen,1,4 Wei Zheng,1,4 Saiping Jiang1,2
1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, People’s Republic of China; 3Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of China; 4Key Laboratory of Element Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Saiping Jiang; Wei Zheng, Email j5145@zju.edu.cn; tizi12345@163.com
Abstract: Sepsis is a life-threatening disease characterized by organ dysfunction resulting from a dysregulated host response to infection, potentially progressing to septic shock. Decreased platelet count and platelet dysfunction serve as crucial clinical markers for assessing the severity and prognosis of sepsis. Historically, platelets have been recognized primarily for their role in hemostasis and thrombosis. However, researches have increasingly demonstrated their significant involvement in innate immunity, contributing to the inflammatory response and coagulation dysfunction in sepsis, mediating sepsis-related complications. The mitigation of the inflammatory response and the suppression of immune mediator release can be achieved through the inhibition of platelet activation, thereby underscoring the therapeutic potential of antiplatelet therapy in ameliorating sepsis. This paper systematically discusses the role of platelets in sepsis, from pathological mechanisms to therapeutic targets, integrating cutting-edge research advances and clinical practice needs to provide a theoretical foundation and translational direction for precision treatment of sepsis.
Keywords: platelets, sepsis, coagulation, inflammatory, antiplatelet therapy
1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, People’s Republic of China; 3Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of China; 4Key Laboratory of Element Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Saiping Jiang; Wei Zheng, Email j5145@zju.edu.cn; tizi12345@163.com
Abstract: Sepsis is a life-threatening disease characterized by organ dysfunction resulting from a dysregulated host response to infection, potentially progressing to septic shock. Decreased platelet count and platelet dysfunction serve as crucial clinical markers for assessing the severity and prognosis of sepsis. Historically, platelets have been recognized primarily for their role in hemostasis and thrombosis. However, researches have increasingly demonstrated their significant involvement in innate immunity, contributing to the inflammatory response and coagulation dysfunction in sepsis, mediating sepsis-related complications. The mitigation of the inflammatory response and the suppression of immune mediator release can be achieved through the inhibition of platelet activation, thereby underscoring the therapeutic potential of antiplatelet therapy in ameliorating sepsis. This paper systematically discusses the role of platelets in sepsis, from pathological mechanisms to therapeutic targets, integrating cutting-edge research advances and clinical practice needs to provide a theoretical foundation and translational direction for precision treatment of sepsis.
Keywords: platelets, sepsis, coagulation, inflammatory, antiplatelet therapy