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已发表论文
用于局部淋巴结实时显像技术的葡聚糖涂覆的氧化铁纳米团簇一锅合成法
Authors Fu C, Zhou H, Wang Y, Liu D, Li J, Deng H, Qi X, Chen T, Zhang LM, Li G
Received 15 December 2016
Accepted for publication 20 March 2017
Published 27 April 2017 Volume 2017:12 Pages 3365—3374
DOI https://doi.org/10.2147/IJN.S130322
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Thiruganesh Ramasamy
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Abstract: The intraoperative
precision cleaning of lymph nodes (LNs) is an essential component of treating
neoplastic disease. To develop efficient probes for the targeted detection of
LNs that could act as carriers for the specific diagnosis and treatment of
metastatic LNs in the future, dextran-coated iron oxide nanoclusters (DIONs)
were synthesized using a one-pot coprecipitation procedure. These modified
DIONs have good water dispersibility, cytocompatibility, an optimum size, and a
stable, dark brown color for LN imaging. In this study, cytotoxicity was
evaluated using lymphatic endothelial cells (LECs) to predict biosafety and
biocompatibility. Most importantly, the effectiveness of DIONs in mapping
perigastric LNs in Sprague Dawley rats following injection into the gastric
submucosal layer was demonstrated. In addition, a long-term tracing in vivo
(from 4 days to 3 months) indicated that the DIONs had good biosafety
and biocompatibility according to an evaluation of the behavior and blood
biochemistry of the rat and a histopathological examination of the important
organs.
Keywords: dextran-coated iron oxide nanoclusters, lymph node mapping, biosafety, lymphatic endothelial cells
Keywords: dextran-coated iron oxide nanoclusters, lymph node mapping, biosafety, lymphatic endothelial cells
