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Authors Zhao S, Ma L, Cao C, Yu Q, Chen L, Liu J
Received 26 September 2016
Accepted for publication 27 January 2017
Published 29 March 2017 Volume 2017:12 Pages 2489—2504
DOI https://doi.org/10.2147/IJN.S123190
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Abstract: At present, it has become evident that inflammation plays a critical
role in tumor growth; meanwhile, chemotherapeutic agents using nanocarriers
have been suggested as a promising strategy in cancer treatment. In this study,
novel redox-responsive micelles were prepared from monomethoxy-poly(ethylene
glycol)-chitosan-S-S-hexadecyl (C16-SS-CS-mPEG).
These micelles were able to carry and deliver drugs into tumor cells. To serve
as a control, monomethoxy-poly(ethylene glycol)-chitosan-C-C-hexadecyl (C16-CC-CS-mPEG) was developed in a similar fashion to
that used to yield C16-CC-CS-mPEG without a
redox-responsive disulfide bond. The cellular uptake mechanisms of both
micelles were determined. The efficient intracellular drug release from
micelles in MCF-7 cells was further confirmed. Results indicated that curcumin
(Cur) could rapidly form C16-SS-CS-mPEG@Cur
micelles when exposed to reducing agents and efficaciously enhance
intracellular accumulation. The cytotoxicity assay demonstrated that C16-SS-CS-mPEG@Cur exhibited satisfactory cytotoxicity
against MCF-7 cells. Anti-inflammation assay results indicated that C16-SS-CS-mPEG@Cur treatment significantly
downregulated tumor necrosis factor (TNF-α) expression and showed good
anti-inflammatory effects in tumor microenvironment. Most importantly,
antitumor effects in vivo showed satisfactory therapeutic effects with C16-SS-CS-mPEG@Cur. Hence, C16-SS-CS-mPEG@Cur micelles can be useful in tumor
therapy.
Keywords: micelles, curcumin, anti-inflammatory
effect, anti-tumor effect, tumor