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辛伐他汀 (Simvastatin) 纳米载体通过调控 BMP4/COX-2 信号通路抗大鼠肠缺血再灌注损伤
Authors Tong F, Dong B, Chai R, Tong K, Wang Y, Chen S, Zhou X, Liu D
Received 29 October 2016
Accepted for publication 28 February 2017
Published 29 March 2017 Volume 2017:12 Pages 2477—2488
DOI https://doi.org/10.2147/IJN.S126063
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 3
Editor who approved publication: Dr Lei Yang
摘要：研究的目的是探索辛伐他汀/PEG-b -PBLG50 共聚复合物通过下调 BMP4/COX-2 信号通路抗大鼠肠缺血再灌注损伤。SD 大鼠通过辛伐他汀或辛伐他汀/PEG-b -PBLG50 共聚复合物 20 mg/kg 预处理，然后缺血 45 min 再灌注 24 h。取大鼠血液和小肠组织，检测血清 IL-4、IL-6、IL-10、TNF-α 和 NO 水平，检测干湿肠比率，SOD 活性、MDA 含量、ROS 表达、BMP4 表达、COX-2 表达、p38MAPK 表达。结果表明：在肠缺血再灌注损伤中辛伐他汀和辛伐他汀/PEG-b -PBLG50 共聚复合物都可以减轻肠氧化应激和炎性损伤，下调 BMP4 和 COX-2 表达，尤其是辛伐他汀/PEG-b -PBLG50 共聚复合物明显减轻肠缺血再灌注损伤。结论：辛伐他汀纳米载体通过下调 BMP4/COX-2 信号通路抗大鼠肠缺血再灌注损伤。
关键词：PEG-b -PBLG50；肠缺血再灌注损伤；BMP4；COX-2
