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非小细胞肺癌患者肺部感染危险因素之间的相互关系及炎症标志物的诊断价值
Authors Qin W, You T , Guo T , Tian R, Cui X , Wang P
Received 12 September 2024
Accepted for publication 14 February 2025
Published 25 February 2025 Volume 2025:18 Pages 1111—1123
DOI https://doi.org/10.2147/IDR.S491507
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sandip Patil
Wenwen Qin,* Tiebin You,* Tai Guo, Ruixin Tian, Xiaoman Cui, Ping Wang
Department of Respiratory Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ping Wang, Email 17201367@hebmu.edu.cn
Objective: To analyze independent risk factors and the distribution of pathogenic bacteria associated with pulmonary infection (PI) in patients with non-small cell lung cancer (NSCLC); and to explore the utility of peripheral blood-related inflammatory markers in the diagnosis of PI after comprehensive treatment of NSCLC.
Methodology: We retrospectively analyzed patients who were first diagnosed with NSCLC and received anti-tumor therapy from January 1, 2022 to December 31, 2022. There were 150 males and 50 females enrolled, and with a median age of 63 years. They were divided into PI (n=59) and non-PI (n=141) groups. The patients’ characteristics, treatment histories, and peripheral blood inflammatory indicators of the two groups were compared.
Results: Eighty-two strains of pathogens were isolated from 59 patients with NSCLC complicated by PI, of which 35 (42.7%) were Gram-negative and 29 (35.4%) were Gram-positive bacteria, 15 (18.3%) were fungi, and 3 (3.7%) were viruses. Logistic regression analysis revealed that ≥ 4 cycles of chemotherapy, radiotherapy, and higher neutrophil count before antineoplastic treatment were independent risk factors for PI in patients with NSCLC (P< 0.05). C-reactive protein (CRP) and CRP-to-albumin ratio (CAR) exhibited high area under the curve values of 0.807 and 0.791, respectively. CRP demonstrated high sensitivity (Cutoff Value:10.095, P< 0.001), whereas CAR had high specificity (Cutoff Value:0.747, P< 0.001) for the early diagnosis of PI in patients with NSCLC.
Conclusion: Gram-negative bacteria were the main pathogens causing PI in patients with NSCLC. Greater than or equal to 4 cycles of chemotherapy, radiotherapy, and elevated neutrophil count before antineoplastic treatment were independent risk factors for PI in patients with NSCLC. Elevated CRP levels and higher CAR demonstrated a certain diagnostic utility for PI in patients with NSCLC after antitumor treatment.
Keywords: non-small cell lung cancer, pulmonary infection, risk factors, inflammatory indicators