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基于适配体的纳米系统在心血管疾病诊断与治疗中的最新进展:综述更新
Received 21 November 2024
Accepted for publication 7 February 2025
Published 25 February 2025 Volume 2025:20 Pages 2427—2443
DOI https://doi.org/10.2147/IJN.S507715
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Dong Wang
Hongqin Yu, Jie Yu, Gang Yao
Department of Cardiovascular Medicine, Yantai Mountain Hospital, Yantai, 264000, People’s Republic of China
Correspondence: Gang Yao, Department of Cardiovascular Medicine, Yantai Mountain Hospital, Yantai, 264000, People’s Republic of China, Email 15666557996@163.com
Abstract: The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity and affinity for target biomolecules, have emerged as promising tools for precise diagnostics and targeted therapies. Their selective binding capabilities provide valuable insights into the molecular mechanisms underlying cardiovascular conditions. When integrated into nanosystems, aptamers enhance the delivery, bioavailability, and stability of diagnostic and therapeutic agents, addressing challenges of solubility and degradation. This integration enables more targeted drug delivery, advanced imaging techniques, and improved therapeutic interventions, ultimately improving the management of cardiovascular diseases. Recent advancements in aptamer selection methodologies, coupled with their unique three-dimensional structures, have significantly expanded their application potential in cardiovascular health. By combining aptamers with nanosystems, novel approaches to cardiovascular disease diagnosis and treatment are emerging, promising enhanced efficacy, safety, and precision. This review explores recent progress in the development and application of aptamer-based nanosystems in cardiovascular diagnostics and therapies.
Keywords: aptamers, nanosystems, cardiovascular diseases, diagnosis, treatment