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动脉粥样硬化中 m6A 修饰与非编码 RNA 相互调控的最新进展
Authors Wang Y, Ling S, Feng H , Hua J, Han Z, Chai R
Received 27 November 2024
Accepted for publication 20 February 2025
Published 25 February 2025 Volume 2025:18 Pages 1047—1073
DOI https://doi.org/10.2147/IJGM.S508197
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Yanlu Wang, Sisi Ling, Hao Feng, Junkai Hua, Zhiyu Han, Renjie Chai
Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, 510260, People’s Republic of China
Correspondence: Renjie Chai, Email ChaiRenjie11@163.com
Abstract: Atherosclerosis, a progressive inflammatory disease of the arteries, remains a leading cause of cardiovascular morbidity and mortality worldwide. Recent years have witnessed the pivotal role of N6-methyladenosine (m6A) RNA methylation in regulating various biological processes, including those implicated in atherosclerosis. Current evidence suggested that m6A regulators (writers, erasers, and readers) participated in the modification of multiple non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), thereby affecting their metabolism and functions. Meanwhile, ncRNAs have also emerged as key modulator of m6A regulators expression in turn. Therefore, understanding the mutual regulation between m6A modifications and ncRNAs is of great significance to identify novel therapeutic targets for atherosclerosis and has great clinical application prospects. This review aims to summarize the recent advances in the reciprocal regulation and provide insights into the interaction between m6A modification and ncRNAs in the context of atherosclerosis.
Keywords: N6-methyladenosine (m6A), non-coding RNAs (ncRNAs), mutual regulation, atherosclerosis, epigenetics