Purpose: Various genetic variants have been reported to be linked to an increased risk of meningioma. However, no confirmed conclusion has been obtained. The purpose of the study was to investigate potential meningioma-associated gene polymorphisms, based on published evidence.
Materials and methods: An updated meta-analysis was performed in September 2016. After electronic database searching and study screening, we selected eligible case-control studies and extracted data for meta-analysis, using Mantel–Haenszel statistics. P -values, pooled odds ratios (ORs), and 95% confidence intervals were calculated.
Results: We finally selected eight genes with ten polymorphisms: MLLT10  rs12770228, CASP8  rs1045485, XRCC1  rs1799782, rs25487, MTHFR  rs1801133, rs1801131, MTRR  rs1801394, MTR  rs1805087, GSTM1  null/present, and GSTT1  null/present. Results of meta-analyses showed that there was increased meningioma risk in case groups under all models of MLLT10  rs12770228 (all OR >1, P <0.001), compared with control groups. Similar results were observed under the allele, homozygote, dominant, and recessive models of MTRR  rs1801394 (all OR >1, P <0.05), and the heterozygote and dominant models of MTHFR  rs1801131 in the Caucasian population (all OR >1, P <0.05). However, no significantly increased meningioma risks were observed for CASP8  rs1045485, XRCC1  rs25487, rs1799782, MTHFR  rs1801133, MTR  rs1805087, or GSTM1/GSTT1  null mutations.
Conclusion: Our updated meta-analysis provided statistical evidence for the role of MLLT10  rs12770228, MTRR  rs1801394, and MTHFR  rs1801131 in increased susceptibility to meningioma.
Keywords: meningioma, meta-analysis, gene, SNP