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Authors Wang M, Zhang C, Song Y, Wang Z, Wang Y, Luo F, Xu Y, Zhao Y, Wu Z, Xu Y
Received 3 November 2016
Accepted for publication 17 December 2016
Published 14 March 2017 Volume 2017:10 Pages 1561—1573
DOI https://doi.org/10.2147/OTT.S126424
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 4
Editor who approved publication: Dr Ingrid Espinoza
Abstract: Breast cancer (BC) is the most common malignant tumor among women, with
high morbidity and mortality. Its onset, development, metastasis, and prognosis
vary among individuals due to the interactions between tumors and host
immunity. Many diverse mechanisms have been associated with BC, with immune
evasion being the most widely studied to date. Tumor cells can escape from the
body’s immune response, which targets abnormal components and foreign bodies,
using different approaches including modification of surface antigens and
modulation of the surrounding environment. In this review, we summarize the
mechanisms and factors that impact the immunoediting process and analyze their
functions in detail.
Keywords: immune evasion, mechanism, breast
cancer, cytokines, apoptosis, PD-L1