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已发表论文
在微/纳米结构钛表面注入镁离子促进其生物活性和成骨细胞分化功能
Authors Wang G, Li J, Zhang W, Xu L, Pan H, Wen J, Wu Q, She W, Jiao T, Liu X, Jiang X
Published Date May 2014 Volume 2014:9(1) Pages 2387—2398
DOI http://dx.doi.org/10.2147/IJN.S58357
Received 27 November 2013, Accepted 10 March 2014, Published 21 May 2014
Abstract: As one of the important ions associated with bone osseointegration, magnesium was incorporated into a micro/nanostructured titanium surface using a magnesium plasma immersion ion-implantation method. Hierarchical hybrid micro/nanostructured titanium surfaces followed by magnesium ion implantation for 30 minutes (Mg30) and hierarchical hybrid micro/nanostructured titanium surfaces followed by magnesium ion implantation for 60 minutes (Mg60) were used as test groups. The surface morphology, chemical properties, and amount of magnesium ions released were evaluated by field-emission scanning electron microscopy, energy dispersive X-ray spectroscopy, field-emission transmission electron microscopy, and inductively coupled plasma-optical emission spectrometry. Rat bone marrow mesenchymal stem cells (rBMMSCs) were used to evaluate cell responses, including proliferation, spreading, and osteogenic differentiation on the surface of the material or in their medium extraction. Greater increases in the spreading and proliferation ability of rBMMSCs were observed on the surfaces of magnesium-implanted micro/nanostructures compared with the control plates. Furthermore, the osteocalcin (OCN ), osteopontin (OPN ), and alkaline phosphatase (ALP ) genes were upregulated on both surfaces and in their medium extractions. The enhanced cell responses were correlated with increasing concentrations of magnesium ions, indicating that the osteoblastic differentiation of rBMMSCs was stimulated through the magnesium ion function. The magnesium ion-implanted micro/nanostructured titanium surfaces could enhance the proliferation, spreading, and osteogenic differentiation activity of rBMMSCs, suggesting they have potential application in improving bone-titanium integration.
Keywords: surface modification, micro/nanostructure, magnesium, ion implantation, osteogenic differentiation
Keywords: surface modification, micro/nanostructure, magnesium, ion implantation, osteogenic differentiation
