已发表论文

术前淋巴细胞与单核细胞的比率可预测初级乙肝病毒阳性肝细胞癌后者在治愈性切除后的生存

 

Authors Li G, Ji J, Yang F, Xu H, Bai Y

Received 12 April 2016

Accepted for publication 23 August 2016

Published 23 February 2017 Volume 2017:10 Pages 1181—1189

DOI https://doi.org/10.2147/OTT.S110411

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 5

Editor who approved publication: Professor Min Li

Background: Both inflammation and immunity are associated with the development of malignancy. The lymphocyte-to-monocyte ratio (LMR) has been confirmed as a prognostic factor for several malignant diseases. The purpose of our study was to analyze prognostic significance of preoperative LMR in hepatitis B virus (HBV)-related hepatocellular carcinoma after curative resection.
Patients and methods: A total of 253 patients with primary HBV-positive hepatocellular carcinoma who underwent a curative operation were enrolled in this retrospective study. The relationship between preoperative LMR and survival outcomes was analyzed through Kaplan–Meier curves and multivariate Cox regression analyses.
Results:
 Patients with a high LMR had a significantly higher mean overall survival than those with a low LMR (67 months vs 55 months, =0.023), and high LMR remained significant for longer survival in the multivariate analysis (hazard ratio, 0.147; 95% confidence interval [CI]: 0.085–0.253; =0.021). Furthermore, patients with a high LMR also had a higher median recurrence-free survival than those with a low LMR in univariate analyses (60 months vs 48 months, =0.026) and multivariate analyses (hazard ratio, 0.317; 95% CI: 0.042–1.023; =0.032). However, the survival benefit was limited to patients with advanced cancer.

Conclusion: LMR was confirmed as an independent prognostic biomarker for primary HBV-positive hepatocellular carcinoma after curative resection.
Keywords: lymphocyte-to-monocyte ratio, survival, HBV, hepatocellular carcinoma