Liqiang Su,1,2 Shouzhi Wu,3 Jinmei Fu,4 Shunli Sun4 

1Physical Education of College, Jiangxi Normal University, Nanchang City, Jiangxi Province, People’s Republic of China; 2School of Physical Education and Sport Science, Fujian Normal University, Fuzhou City, Fujian Province, People’s Republic of China; 3School of Public Foundation, Wannan Medical College, Wuhu City, Anhui Province, People’s Republic of China; 4Jiangxi Sports Science Medical Center, Nanchang City, Jiangxi Province, People’s Republic of China

Correspondence: Liqiang Su; Shouzhi Wu, Email s-2005100153@163.com; 383678907@qq.com

Purpose: This study aims to explore the relationship between BMI and chronic inflammation and to investigate the interaction and mediation of physical activity (PA), cardiopulmonary function, and visfatin.
Methods: A total of 119 participants were included in the study, 60 in the obesity group, 30 in the normal weight group, and 29 in the overweight group. PA, VO2max, visfatin, high-sensitivity C-reactive protein (hs-CRP), and four blood lipid indices (TC, TG, HDLC, LDLC) were analyzed. Regression analysis was used to understand the effect of BMI on chronic inflammation. Covariate analysis was conducted to screen effective covariates affecting BMI to predict chronic inflammation and test the interaction and intermediary role of effective covariates.
Results: The increase in BMI could aggravate chronic inflammation. PA, VO2max, and visfatin had interactive effects on BMI affecting chronic inflammation, and visfatin played an intermediary role in BMI affecting chronic inflammation. The effect value of BMI on chronic inflammation in terms of low PA was 3.5 times higher than that of high PA, that of low VO2max was 2.8 times higher than that of high VO2max, and that of high visfatin was 3.65 times higher than that of low visfatin. Approximately 19.35% of the effect was mediated by visfatin.
Conclusion: An increase in BMI can aggravate chronic inflammation. Increases in PA and VO2max can alleviate chronic inflammation, and visfatin plays a positive mediating role.

Keywords: obesity, chronic inflammation, physical activity, VO2max, visfatin