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Authors Huang Y, Sun Y, Peng P, Zhu S, Sun W, Zhang P
Received 4 November 2016
Accepted for publication 17 December 2016
Published 23 February 2017 Volume 2017:10 Pages 1165—1172
DOI https://doi.org/10.2147/OTT.S126637
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Lucy Goodman
Peer reviewer comments 3
Editor who approved publication: Dr Samir Farghaly
Purpose: Evidence from an increasing number of studies has demonstrated that the
neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor for various
cancers. However, it is unclear whether NLR predicts prognosis in esophageal
squamous cell carcinoma (ESCC). We conducted a meta-analysis to investigate the
prognostic and clinicopathologic significance of NLR in patients with ESCC.
Patients and methods: Selected studies were identified by searches in
PubMed, Embase, and Web of Science databases and filtered using our prepared
criteria. The hazard ratio (HR) and odds ratio were chosen as effect measures
to assess the prognostic role of NLR and its clinicopathologic significance in
ESCC. In total, nine studies containing 2,513 patients were enrolled.
Results: We demonstrated that elevated NLR was associated with
worse overall survival in ESCC patients (pooled HR =1.314; 95% confidence
interval, 1.164–1.484; P <0.001). Elevated NLR was also
associated with unfavorable characteristics regarding depth of tumor invasion,
tumor size, clinical stage, and differentiation degree.
Conclusion: The results of our meta-analysis suggest that a high
NLR value might represent a poor prognosis and worse clinicopathologic
characteristics for patients with ESCC.
Keywords: ESCC, NLR, prognosis, meta-analysis,
inflammation