已发表论文

中国人群中 TP53  基因 Arg72Pro 多态性与 Wilms 肿瘤风险的关系

 

Authors Fu W, Zhuo Z, Jia W, Zhu J, Zhu S, Lin Z, Wang F, Xia H, He J, Liu G

Received 23 December 2016

Accepted for publication 3 February 2017

Published 23 February 2017 Volume 2017:10 Pages 1149—1154

DOI https://doi.org/10.2147/OTT.S131014

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Narasimha Reddy Parine

Peer reviewer comments 4

Editor who approved publication: Dr Yao Dai

Abstract: Wilms’ tumor is one of the most prevalent pediatric malignancies, ranking fourth in childhood cancer worldwide. TP53  is a critical tumor suppressor gene, which encodes a 53 kDa protein, p53. The p53 functions to protect against cancer by regulating cell cycle and apoptosis and maintaining DNA integrity. TP53  gene is highly polymorphic. Several TP53  gene polymorphisms have been considered to be associated with cancer risk. Of them, a nonsynonymous polymorphism, Arg72Pro (rs1042522 C>G), has been most extensively studied for the association with cancer risk; however, few studies have investigated its effect on Wilms’ tumor. Because of the central role of p53 in cell cycle control, the TP53  gene Arg72Pro polymorphism is also a good potential candidate predisposition locus for this pediatric cancer. We genotyped this polymorphism in 145 patients and 531 cancer-free controls recruited from Chinese children by Taqman methodology. Overall, our result suggested a lack of association between the TP53  gene Arg72Pro polymorphism and Wilms’ tumor. In the stratified analysis, we found that carriers of CG/GG genotypes had a significantly increased Wilms’ tumor risk in children not older than 18 months (adjusted odds ratio =2.04, 95% confidence interval =1.003–4.13, =0.049) compared with CC genotype carriers. Our study indicated that the TP53  gene Arg72Pro polymorphism may have a weak, age-related effect on Wilms’ tumor risk in Chinese children. These findings need further validations in other populations with larger sample size.
Keywords: TP53 , polymorphism, Wilms’ tumor, susceptibility