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Authors Zhang Y, Zhou Y, Zhou X, Zhao B, Chai J, Liu H, Zheng Y, Wang J, Wang Y, Zhao Y
Received 22 October 2016
Accepted for publication 18 January 2017
Published 21 February 2017 Volume 2017:12 Pages 1441—1452
DOI https://doi.org/10.2147/IJN.S125409
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Abstract: Prosthetic meshes used for hernioplasty are usually complicated with
chronic pain due to avascular fibrotic scar or mesh shrinkage. In this study,
we developed a tissue-engineered mesh (TEM) by seeding autologous bone
marrow-derived mesenchymal stem cells onto nanosized fibers decellularized
aorta (DA). DA was achieved by decellularizing the aorta sample sequentially
with physical, mechanical, biological enzymatic digestion, and chemical
detergent processes. The tertiary structure of DA was constituted with micro-,
submicro-, and nanosized fibers, and the original strength of fresh aorta was
retained. Inguinal hernia rabbit models were treated with TEMs or acellular
meshes (AMs). After implantation, TEM-treated rabbit models showed no hernia
recurrence, whereas AM-treated animals displayed bulges in inguinal area. At
harvest, TEMs were thicker, have less adhesion, and have stronger mechanical
strength compared to AMs (P <0.05).
Moreover, TEM showed better cell infiltration, tissue regeneration, and
neovascularization (P <0.05).
Therefore, these cell-seeded DAs with nanosized fibers have potential for use
in inguinal hernioplasty.
Keywords: nanobiomaterial, tissue engineering,
inguinal hernia, hernioplasty, decellularized aorta