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Authors Pei S, Zhou C, Zhu Y, Huang B
Received 29 November 2016
Accepted for publication 17 January 2017
Published 21 February 2017 Volume 2017:10 Pages 445—450
DOI https://doi.org/10.2147/JPR.S128992
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Lucy Goodman
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Enrica Santarcangelo
Aim: This review was performed to investigate the effect of ondansetron on
the prevention of propofol injection pain.
Methods: PubMed, Cochrane Library, and China National Knowledge
Infrastructure (CNKI) were searched for randomized controlled trials (RCTs) of
ondansetron in preventing the pain on injection of propofol. Then, RevMan 5.2
was adopted to conduct a meta-analysis on propofol injection pain.
Results: Ten RCTs, totaling 782 patients, were included in this
analysis. The meta-analysis showed that: 1) compared with the control group,
the ondansetron group was related to a decreasing incidence of propofol
injection pain, and it was statistically significant (risk ratio [RR] = 0.41,
95% confidence interval [CI, 0.34, 0.49], P < 0.00001); 2) compared with the
incidence of propofol injection pain in the lidocaine group, there was no
difference and no statistical significance (RR = 1.28, 95% CI [0.85, 1.93], P = 0.25); 3) no statistically
significant differences were found between the ondansetron and magnesium
sulfate groups in the incidence of propofol injection pain (RR = 1.20, 95% CI
[0.87, 1.66], P = 0.27); and 4) the incidence of
ondansetron group igniting moderate pain (RR = 0.37, 95% CI [0.26, 0.52], P < 0.00001) and severe pain (RR =
0.27, 95% CI [0.17, 0.43] P < 0.00001) was less likely to occur
during the injection of propofol compared with the control group, but there was
no difference between the ondansetron and control groups in the incidence of
mild propofol injection pain (RR = 0.83, 95% CI [0.63, 1.10], P = 0.20).
Conclusion: Ondansetron can effectively prevent propofol injection
pain, and the effect is similar to that of magnesium sulfate and lidocaine.
Keywords: ondansetron, propofol injection pain,
meta-analysis