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Authors Cao L, Weng W, Chen X, Zhang J, Zhou Q, Cui J, Zhao Y, Shin J, Su J
Received 18 October 2016
Accepted for publication 20 December 2016
Published 17 February 2017 Volume 2017:12 Pages 1341—1352
DOI https://doi.org/10.2147/IJN.S124965
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Abstract: Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into
calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone
cements. The introduction of nl-MS improved the in vitro degradability of
nl-MSC cements, which could neutralize acidic degradable products of calcium
sulfate and prevented the pH from dropping. The cements were implanted into the
bone defects of femur bone of rabbits, and the results of histological and
immunohistochemical analysis revealed that massive new bone tissue formed in
the defects while the cements were degradable, indicating that the osteogenesis
and degradability of the nl-MSC cements were much better than the control
calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression
of vascular endothelial growth factor and collagen type I for nl-MSC cements
was higher than CSD, indicating that addition of nl-MS into the cements
enhanced vascularization and osteogenic differentiation. The results suggested
that the nl-MSC cements with good biocompatibility and degradability could
promote vascularization and osteogenesis, and had great potential to treat bone
defects.
Keywords: bone cements, nanoporous lithium
doping magnesium silicate, degradability, vascularization, osteogenesis