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Authors Chen HY, Chen YM, Wu J, Yang FC, Lv Z, Qian YG, Zheng SS
Received 15 June 2016
Accepted for publication 2 September 2016
Published 13 February 2017 Volume 2017:10 Pages 803—810
DOI https://doi.org/10.2147/OTT.S115035
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Narasimha Reddy Parine
Peer reviewer comments 2
Editor who approved publication: Dr Ingrid Espinoza
Objective: To investigate the correlations of two hepatocyte growth factor (HGF ) gene polymorphisms (rs5745652
and rs2074725) and their protein expression levels with the efficacy of
transhepatic arterial chemotherapeutic embolism (TACE) and prognosis in
patients with primary liver cancer (PLC).
Methods: From March 2011 to June 2012, 109 PLC patients (the case group) who
chose TACE as primary treatment and 80 healthy people (the control group) who
had undergone physical examination in The First Affiliated Hospital, Zhejiang
University were selected during the same period. Gene polymorphisms of HGF rs5745652
and HGF rs2074725
were detected. Serum HGF level, treating efficacy, survival quality, and 3-year
survival rate for PLC patients who received TACE were observed.
Results: There were significant differences in genotype and allele frequencies of HGF rs5745652
and HGF rs2074725,
between the case and control groups (all P <0.05). Compared with CT+TT
genotype of HGF rs5745652,
patients carrying CC genotype had lower serum HGF levels,
higher efficacy, better survival quality, and prolonged 3-year survival rate
(all P <0.05).
In rs2074725, patients carrying CA+AA genotype had lower serum HGF levels,
higher efficacy, better survival quality, and prolonged 3-year survival rate
compared with patients carrying rs2074725 CC genotype (all P <0.05). Gene
polymorphisms of HGF rs5745652
and HGF rs2074725,
tumor size, and Barcelona Clinic Liver Cancer stage were independent prognostic
factors for PLC (P <0.05).
Conclusion: Our results indicated that HGF gene
polymorphisms affect TACE efficacy and survival quality of PLC patients.
Patients with HGF CC
genotype of rs5745652 and CA+AA genotype of rs2074725 had decreased HGF level,
better curative effect, high survival quality, and a good prognosis after TACE
treatment.
Keywords: primary liver cancer, hepatocyte growth factor, rs5745652, rs2074725,
gene polymorphisms, transhepatic arterial chemotherapeutic embolism efficacy,
HGF, TACE efficacy