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Authors Chan KH, Lee WH, Zhuo S, Ni M
Received 31 October 2016
Accepted for publication 27 December 2016
Published 9 February 2017 Volume 2017:12 Pages 1171—1182
DOI https://doi.org/10.2147/IJN.S126154
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Yu Mi
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Abstract: The harnessing of peptides in biomedical applications is a recent hot
topic. This arises mainly from the general biocompatibility of peptides, as
well as from the ease of tunability of peptide structure to engineer desired
properties. The ease of progression from laboratory testing to clinical trials
is evident from the plethora of examples available. In this review, we compare
and contrast how three distinct self-assembled peptide nanostructures possess
different functions. We have 1) nanofibrils in biomaterials that can interact
with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload
and also be bioimaged, and 3) nanotubes that can serve as cross-membrane
conduits and as a template for nanowire formation. Through this review, we aim
to illustrate how various peptides, in their various self-assembled
nanostructures, possess great promise in a wide range of biomedical
applications and what more can be expected.
Keywords: peptides, self-assembly,
nanotechnology