Yan Yang,1 Yong Wang,2 Xiao-Yang Pei2 

1Department of General Practice, The Hospital Affiliated to Inner Mongolia Minzu University, Tongliao, People’s Republic of China; 2Department of Cardiology, Shenzhen Luohu Hospital Group Luohu People’s Hospital (The Third Affiliated Hospital of Shenzhen University), Shenzhen, People’s Republic of China

Correspondence: Yong Wang, Email drwangyong2016@163.com

Background: Previous studies have suggested that triglyceride glucose-body mass index (TyG-BMI) is associated with cardiovascular mortality in patients undergoing peritoneal dialysis. However, the predictive value of TyG-BMI in the prognosis of acute myocardial infarction (AMI) remains unclear.
Methods: In total, 408 AMI patients who underwent PCI were consecutively included in this study. All included patients were then divided into three groups according to tertiles of TyG-BMI. The association between TyG-BMI and major adverse cardiovascular and cerebrovascular events (MACCEs) were investigated.
Results: Participants were divided into three groups: tertile 1(≤ 199.4, n=136), tertile 2 (199.4– 231.8, n=136), and tertile 3 (≥ 231.8, n=136). Eighty (19.6%) patients had MACCEs: 18 (13.2%) in tertile 1, 26 (19.1%) in tertile 2, and 36 (25.7%) in tertile 3. The incidence of MACCEs increased as the tertiles of TyG-BMI increased (p< 0.05). Multivariate Cox regression analysis revealed that diabetes mellitus and TyG-BMI were independent predictors of MACCEs in AMI patients after PCI (p< 0.05). The receiver operating characteristic (ROC) curve showed that when TyG-BMI was ≥ 192.4, the sensitivity and specificity were 60.1% and 65.4%, respectively, and the area under the ROC curve (AUC) was 0.632 (95% confidence interval [CI]: 0.562– 0.703; p < 0.001).
Conclusion: Elevated TyG-BMI level was an independent predictor of the composite MACCEs in patients with AMI after PCI.

Keywords: triglyceride glucose body mass index, major adverse cardiac and cerebrovascular event, acute myocardial infarction, PCI