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已发表论文
紫杉醇 (Paclitaxel) 和/或顺铂 (Cisplatin) 引起的眼部神经毒性：一例病例报告与文献综述
Authors Li Y, Li YP, Li JY, Pi GL, Tan WY
Published Date July 2014 Volume 2014:7 Pages 1361—1366
DOI http://dx.doi.org/10.2147/OTT.S65774
Received 8 April 2014, Accepted 13 May 2014, Published 31 July 2014
Abstract: Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors. Both may cause moderate or severe neurotoxicity, but ocular neurotoxicity is also occasionally reported. A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports. Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.
Keywords: cytotoxic drugs, PTX, CDDP, oncology, chemotherapy
