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含康替唑胺方案成功治疗女性慢性肾移植功能不全顽固性结核性腹膜炎
Authors Liu W, Yang L , Qin H, Zhang P
Received 22 February 2024
Accepted for publication 24 June 2024
Published 1 July 2024 Volume 2024:17 Pages 2713—2718
DOI https://doi.org/10.2147/IDR.S465350
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Suresh Antony
Weijian Liu,* Liangzi Yang,* Hongjuan Qin, Peize Zhang
Department of Pulmonary Medicine and Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Peize Zhang, Email 82880246@qq.com
Abstract: Tuberculosis(TB) is a serious infection that affects transplant recipients, particularly in high TB burden countries. Clinical presentation of these patients is atypical, and the care and management are frequently tricky as multi-drug interaction and intolerable adverse effects. Contezolid, a novel oxazolidinone antibacterial agent, had been demonstrated to be effective for TB in vitro and had been shown in some clinical cases with a more favorable safety profile than linezolid, the first-generation oxazolidinone, which had a commonly seen myelosuppression and neuropathy. Additionally, Contezolid has a unique metabolic mechanism that leads to less drug interaction. Here, we report a case of multi-system TB in a transplant recipient with chronic kidney allograft dysfunction. She was intolerant to most first and second-line anti-TB drugs and repeatedly developed ascites and nocturnal low-grade fever. She finally achieved good efficacy and safety results after enhanced anti-TB treatment with the addition of contezolid. Given the increased risk of TB in patients with organ transplantation and multi-drug interaction in patients with severe comorbidities, further clinical studies are needed to investigate the application and appropriate dosage of contezolid in patients with active TB.
Keywords: tuberculosis, contezolid, kidney dysfunction, kidney transplantation, tuberculous peritonitis