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已发表论文
用于改善穿过大脑屏障进行中枢神经系统药物传递的当前方法
Authors Lu CT, Zhao YZ, Wong HL, Cai J, Peng L, Tian XQ
Published Date May 2014 Volume 2014:9(1) Pages 2241—2257
DOI http://dx.doi.org/10.2147/IJN.S61288
Received 24 January 2014, Accepted 1 March 2014, Published 10 May 2014
Abstract: Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood–brain barrier and the blood–cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed.
Keywords: drug delivery system, blood–brain barrier (BBB), central nervous system, brain-targeted therapy, cerebrospinal fluid (CSF)
Keywords: drug delivery system, blood–brain barrier (BBB), central nervous system, brain-targeted therapy, cerebrospinal fluid (CSF)
