已发表论文

乙肝病毒感染的妊娠期肝内胆汁淤积症对围产期结果的影响

 

Authors Hu Y, Ding YL, Yu L

Published Date May 2014 Volume 2014:10 Pages 381—385

DOI http://dx.doi.org/10.2147/TCRM.S61530

Received 29 January 2014, Accepted 25 March 2014, Published 23 May 2014


Introduction: To investigate the impact of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus (HBV) infection on perinatal outcomes.
Methods: In the study, 200 pregnant women were divided into four groups, including 50 cases with ICP and HBV infection, 50 cases with ICP, 50 cases with HBV infection, and 50 healthy pregnancies. The delivery process and perinatal outcomes were analyzed among different groups.
Results: When compared to the healthy pregnancy group, significantly increased rates of premature rupture of membranes, meconium-stained amniotic fluid, and cesarean section were observed in cases of ICP, HBV infection, or ICP patients with HBV (<0.05). Specifically, the rates of HBV infection in the newborn, fetal distress, neonatal asphyxia, and birth defects in the newborn, and infant Apgar scores were higher in ICP pregnancies with HBV (56%, 48%, 16%, and 48%, respectively) than in the other groups (<0.05).
Conclusion: ICP combined with HBV infection has a clear influence on perinatal infant outcomes.
Keywords: premature rupture of membranes, meconium-stained amniotic fluid, cesarean section, fetal distress, neonatal asphyxia, birth defects, Apgar scores