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已发表论文
YY1 的表达与食管鳞状细胞癌进展和转移相关
Authors Luo J, Jiang X, Cao L, Dai K, Zhang S, Ge X, Zhou X, Lu X
Published Date September 2014 Volume 2014:7 Pages 1753—1759
DOI http://dx.doi.org/10.2147/OTT.S66667
Received 22 April 2014, Accepted 30 July 2014, Published 26 September 2014
Approved for publication by Dr Faris Farassati
Objective: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Yin Yang 1 (YY1) is a ubiquitous and multifunctional zinc-finger transcription factor that plays important biological functions in cell homeostasis and tumorigenesis. The purpose of this study was to investigate the expression of YY1 in different ESCC tissues and the potential relationship with clinicopathological features.
Methods: One hundred and four ESCC tissues were collected in this study. The protein levels of YY1 were measured by immunohistochemistry. TE-1 cell invasion in vitro was assessed using the Transwell assay.
Results: There were no obvious differences between expression levels in patients over age 64 and those younger than 64, and no noticeable distinction was observed between males and females. However, the YY1 protein level was significantly higher in ESCC tissues with lymph node metastasis than those without lymph node metastasis (P =0.042). Furthermore, the expression of the YY1 protein was stronger in stage III–IV patients than in stage I–II patients (P =0.002), but the protein levels between different histological grades (well, moderate, or poor) showed no statistical significance. Similarly, there was no difference in YY1 expression in patients with or without lymphatic invasion. The Transwell assay revealed that the overexpression of YY1 promoted the invasion ability of TE-1 cells and the inhibition of YY1 could reverse this promotion.
Conclusion: YY1 expression was associated with TNM stage and lymph node metastasis, suggesting that YY1 can influence human esophageal cancer progression and metastasis.
Keywords: immunohistochemistry, transwell assay, clinicopathological features, invasion
Methods: One hundred and four ESCC tissues were collected in this study. The protein levels of YY1 were measured by immunohistochemistry. TE-1 cell invasion in vitro was assessed using the Transwell assay.
Results: There were no obvious differences between expression levels in patients over age 64 and those younger than 64, and no noticeable distinction was observed between males and females. However, the YY1 protein level was significantly higher in ESCC tissues with lymph node metastasis than those without lymph node metastasis (P =0.042). Furthermore, the expression of the YY1 protein was stronger in stage III–IV patients than in stage I–II patients (P =0.002), but the protein levels between different histological grades (well, moderate, or poor) showed no statistical significance. Similarly, there was no difference in YY1 expression in patients with or without lymphatic invasion. The Transwell assay revealed that the overexpression of YY1 promoted the invasion ability of TE-1 cells and the inhibition of YY1 could reverse this promotion.
Conclusion: YY1 expression was associated with TNM stage and lymph node metastasis, suggesting that YY1 can influence human esophageal cancer progression and metastasis.
Keywords: immunohistochemistry, transwell assay, clinicopathological features, invasion
