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已发表论文
转录因子 KLF4 作为一个独立的预测标志物，用于乳腺癌新辅助化疗中病理完全缓解指标：一项病例对照研究
Authors Dong MJ, Wang LB, Jiang ZN, Jin M, Hu WX, Shen JG
Published Date October 2014 Volume 2014:7 Pages 1963—1969
DOI http://dx.doi.org/10.2147/OTT.S68340
Received 24 May 2014, Accepted 9 September 2014, Published 24 October 2014
Approved for publication by Professor Jianmin Xu
Background: To identify whether a stem cell biomarker, KLF4, may predict the pathologic tumor response to neoadjuvant chemotherapy for patients with locally advanced breast cancer.
Methods: Twelve locally advanced breast cancer patients who achieved pathologic complete remission (pCR) after neoadjuvant chemotherapy were identified and for each, three non-pCR breast cancer patients – matched for age, clinical tumor–node–metastasis stage, and neoadjuvant chemotherapy cycles – were selected. The relationship between KLF4 expression in the core needle biopsied cancer tissue and patient pCR rate was assessed using univariate and multivariate analysis.
Results: Receiver operating characteristic curve analysis showed that the patients with a histoscore of KLF4 expression >0.18 had a lower pCR rate. Multivariable analysis showed that higher KLF4 expression (odds ratio 0.013; 95% confidence interval 0.013–0.444; P =0.004) was independently correlated with a lower pCR rate after neoadjuvant chemotherapy.
Conclusion: KLF4 overexpression was associated with lower pCR in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy. This study suggests that KLF4 may serve as a predictor for pCR in patients with breast cancer after neoadjuvant chemotherapy.
Keywords: locally advanced breast cancer, predictor, stem cell biomarker, pathologic tumor response
Methods: Twelve locally advanced breast cancer patients who achieved pathologic complete remission (pCR) after neoadjuvant chemotherapy were identified and for each, three non-pCR breast cancer patients – matched for age, clinical tumor–node–metastasis stage, and neoadjuvant chemotherapy cycles – were selected. The relationship between KLF4 expression in the core needle biopsied cancer tissue and patient pCR rate was assessed using univariate and multivariate analysis.
Results: Receiver operating characteristic curve analysis showed that the patients with a histoscore of KLF4 expression >0.18 had a lower pCR rate. Multivariable analysis showed that higher KLF4 expression (odds ratio 0.013; 95% confidence interval 0.013–0.444; P =0.004) was independently correlated with a lower pCR rate after neoadjuvant chemotherapy.
Conclusion: KLF4 overexpression was associated with lower pCR in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy. This study suggests that KLF4 may serve as a predictor for pCR in patients with breast cancer after neoadjuvant chemotherapy.
Keywords: locally advanced breast cancer, predictor, stem cell biomarker, pathologic tumor response
