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已发表论文
Gli3 基因沉默增强卵巢癌对环杷抑制作用
Authors Liu HY, Dong Z
Published Date October 2014 Volume 2014:7 Pages 2007—2011
DOI http://dx.doi.org/10.2147/OTT.S57346
Received 10 November 2013, Accepted 24 January 2014, Published 30 October 2014
Abstract: Ovarian cancer is a leading gynecological malignancy associated with high mortality. Hedgehog signaling has been found to be important for cell proliferation and tumor growth for multiple cancers, including ovarian cancer. The present study showed that the drug cyclopamine, which blocks the hedgehog signaling pathway, could reduce cancer cell growth and proliferation and induce cell apoptosis. In addition, the silencing of the glioma-associated oncogene (Gli)3, a downstream component of the hedgehog signaling pathway, could further enhance the antitumor effects of cyclopamine. Our results suggest that Gli3 may act as resistance to cyclopamine’s effect on tumor growth. The combined treatment of cyclopamine application and Gli3 silencing therapy, therefore, may provide novel directions for clinical management of ovarian cancer.
Keywords: ovarian cancer, hedgehog, cyclopamine, proliferation, apoptosis, Gli3
Keywords: ovarian cancer, hedgehog, cyclopamine, proliferation, apoptosis, Gli3
