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通过使用聚乙二醇化的磷脂膜涂覆，改善层状双氢氧化物纳米颗粒的药物动力学和抗肿瘤活性

 

Authors Yan MN, Zhang ZG, Cui SM, Lei M, Zeng K, Liao YH, Chu WJ, Deng YH, Zhao CS

Published Date October 2014 Volume 2014:9(1) Pages 4867—4878

DOI http://dx.doi.org/10.2147/IJN.S69729

Received 20 June 2014, Accepted 8 August 2014, Published 21 October 2014

Approved for publication by Professor Thomas J. Webster

Abstract: Layered double hydroxide (LDH) has attracted considerable attention as a drug carrier. However, because of its poor in vivo behavior, polyethylene glycolylated (PEGylated) phospholipid must be used as a coformer to produce self-assembled core–shell nanoparticles. In the present study, we prepared a PEGylated phospholipid-coated LDH (PLDH) (PEG-PLDH) delivery system. The PEG-PLDH nanoparticles had an average size of 133.2 nm. Their core–shell structure was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy. In vitro liposome-cell-association and cytotoxicity experiments demonstrated its ability to be internalized by cells. In vivo studies showed that PEGylated phospholipid membranes greatly reduced the blood clearance rate of LDH nanoparticles. PEG-PLDH nanoparticles demonstrated a good control of tumor growth and increased the survival rate of mice. These results suggest that PEG-PLDH nanoparticles can be a useful drug delivery system for cancer therapy.
Keywords: lipid membrane, positive charge, delivery system, cancer therapy







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